Blood Aldosterone-to-Renin Ratio, Ambulatory Blood Pressure, and Left Ventricular Mass in Children - 07/08/11
, Phyllis A. Richey, PhD a, b, Thomas G. DiSessa, MD c, Bruce S. Alpert, MD b, d, Deborah P. Jones, MD, MS b, d
Reprint requests: Rongling Li, MD, PhD, Department of Preventive Medicine, University of Tennessee Health Science Center, 66 N Pauline Street, Suite 633, Memphis, TN 38163.Abstract |
Objective |
To assess the blood aldosterone-to-renin ratio (ARR) and its relationship to ambulatory blood pressure (ABP) and left ventricular mass (LVM) in children.
Study design |
A cross-sectional clinical study was conducted in 102 children (71.6% African American; 62.7% male) ranging in age from 7 to 18 years (mean, 13.6 years; median, 14 years). ABP (24-hour monitoring) was expressed as blood pressure index (BPI; mean blood pressure/95th percentile by sex and height). LVM was measured by echocardiography and expressed as an index (LVMI = g/height [m]2.7). Regression analyses were used to estimate associations.
Results |
African-American children had significantly lower serum aldosterone concentration and plasma renin activity compared with European-American children (aldosterone: 5.9 ng/dL vs 11.4 ng/dL, P < .0001; renin: 1.6 ng/mL/hour vs 2.8 ng/mL/hour, P = .01). However, ARR was not significantly different by race. ARR was not associated with 24-hour ABP but was significantly associated with LVMI (β = 0.4 g/m2.7; P = .02) after adjustment for the ratio of 24-hour urine Na to creatinine excretion, body mass index z- score, and ABP index.
Conclusions |
The data indicated a significant association between ARR and LVMI, but not ABP, in children, suggesting early cardiac remodeling associated with a high ARR.
Le texte complet de cet article est disponible en PDF.Mots-clés : AA, ABP, ABPI, ABPM, ARR, BMI, BP, BPI, DBP, DBPI, EA, HTN, IVS, LVID, LVM, LVMI, PRA, PWT, RAAS, SBP, SBPI
Plan
| Supported by grants from the Children’s Foundation Research Center at Le Bonheur Children’s Medical Center and the University of Tennessee Health Science Center, the US Public Health Service (MO1 RR-00211), and the National Institutes of Health (NHLBI 5K23HL83910-2). The authors declare no conflicts of interest. |
Vol 155 - N° 2
P. 170-175 - août 2009 Retour au numéro
Article précédent
- Pre-hypertension and Hypertension in Pediatrics: Don’t Let the Statistics Hide the Pathology
- R. Thomas Collins, Bruce S. Alpert
- Clinical Characterization of Pediatric Pulmonary Hypertension: Complex Presentation and Diagnosis
- Rosa Laura E. van Loon, Marcus T.R. Roofthooft, Magdalena van Osch-Gevers, Tammo Delhaas, Jan L.M. Strengers, Nico A. Blom, Ad Backx, Rolf M.F. Berger
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?