Mononuclear cell subpopulations in CSF and blood of children with bacterial meningitis - 07/08/11
, Madoka Kajimoto, Takeshi Matsushige, Masahiro Shiraishi, Yasuo Suzuki, Susumu Furukawa
Correspondence to: Tel.: +81 836 22 2258; fax: +81 836 22 2257.Summary |
Objectives |
To elucidate mononuclear cell subsets of the cerebrospinal fluid (CSF) in order to investigate the pathogenesis of bacterial meningitis (BM).
Methods |
Mononuclear cell and lymphocyte subsets in CSF and peripheral blood from 10 children with acute-stage BM before treatment on the same day were measured by flow cytometry. The control subjects for the subsets of peripheral blood were 15 healthy children.
Results |
The percentages of CD14+ monocytes/macrophages (median: 56.5%), activated CD14+CD16+ monocytes/macrophages (20.9%), and CD14+CD16+ cells among total CD14+ cells (37.9%) in the CSF were significantly higher than those in the blood of children with BM (p<0.01, p<0.01, and p<0.05, respectively), which were significantly higher than those of the controls (p<0.001, p<0.001, p<0.05, respectively). The percentages of CD3+ (77.3%), CD4+ (45.2%), and CD8+ T cells (32.6%) in the CSF were significantly higher than those in the blood of affected children (p<0.01, p<0.01, and p<0.05, respectively). The percentages of CD3+, CD4+, and CD8+ T cells in the blood of children with BM were significantly lower than those of controls (all p<0.001). The percentages of CD20+ B cells (6.9%) in the CSF were significantly lower than those in the blood of affected children (p<0.01), which were significantly higher than those of controls (p<0.001).
Conclusion |
The percentages of monocytes/macrophages and T cells in CSF were higher than those in blood in children with BM.
Le texte complet de cet article est disponible en PDF.Keywords : Bacterial meningitis, B cells, Cerebrospinal fluid, Monocytes/macrophages, T cells
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Vol 58 - N° 1
P. 28-31 - janvier 2009 Retour au numéro
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