Trends in invasive pneumococcal disease among older adults in Olmsted County, Minnesota - 07/08/11
, Imad M. Tleyjeh a, b, Brian D. Lahr c, Lisa M. Nyre d, Abinash Virk a, Larry M. Baddour a
Corresponding author. Present address: University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, Cooper University Hospital, Infectious Diseases Division, 401 Haddon Ave, Camden, New Jersey 08103, USA. Tel.: +1 856 757 7767; fax: +1 856 757 7803.Summary |
Objective |
Following the introduction of a 7-valent pneumococcal conjugate vaccine (PCV-7) for children in early 2000 in the United States, a decrease in the incidence of invasive pneumococcal disease (IPD) was seen in adults, likely due to a herd effect. However, there have been recent increases in IPD in adults caused by Streptococcus pneumoniae serotypes not included in PCV-7, so called “replacement disease”. We performed a population-based study to further investigate this emerging concern.
Methods |
Population-based incidence study in Olmsted County, Minnesota, United States, in adults aged ≥50 years.
Results |
From 1/1/1995 to 12/31/2007, 104 cases of IPD were identified in Olmsted County in adults aged ≥50 years. We found a 45% increase in the incidence rate of IPD from 2001–2003 (17.7 cases per 100,000 person-years) to 2004–2007 (32.1 cases per 100,000 person-years) (p=0.029). From 2002–2004 to 2005–2007, the incidence rate of IPD caused by S. pneumoniae serotypes not included in PCV-7 increased from 9.2 to 32.8 cases per 100,000 person-years (p<0.001).
Conclusion |
A recent increase in the incidence of IPD in adults aged ≥50 years was demonstrated in Olmsted County, Minnesota due to serotypes not found in PCV-7. These findings are unique and merit further investigation.
Le texte complet de cet article est disponible en PDF.Keywords : Streptococcus pneumoniae, Pneumococcal infections, Incidence, Aged, Cohort studies
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Vol 59 - N° 3
P. 188-193 - septembre 2009 Retour au numéro
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