Allergic rhinitis as a predictor for wheezing onset in school-aged children - 07/08/11
, Sabina Illi, PhD a, Markus J. Ege, MD a, Susanne Lau, MD b, Thomas Keil, MD, MSc c, Ulrich Wahn, MD b, Erika von Mutius, MD aMulticentre Allergy Study (MAS) group
Reprint requests: Mascha K. Rochat, MD, Dr. von Haunersche Kinderklinik, Lindwurmstrasse 4, 80337 Munich, Germany.Abstract |
Background |
Rhinitis in older children and adults has been shown to be a predictor for adolescent- and adult-onset asthma. These findings suggest an interaction between the upper and lower airways. Whether rhinitis is a predictor for childhood-onset asthma is unknown.
Objective |
We sought to investigate whether rhinitis in early childhood is an independent predictor for wheezing between the ages of 5 and 13 years in the German Multicentre Allergy Study birth cohort.
Methods |
The German Multicentre Allergy Study cohort initially included 1314 healthy children. They were followed from birth to the age of 13 years with regular questionnaires and interviews. Specific IgE levels were measured at yearly intervals. Airway hyperresponsiveness was assessed at 7 years.
Results |
Allergic rhinitis until the age of 5 years was found to be a predictor for developing wheezing between the ages of 5 and 13 years, with an adjusted relative risk of 3.82 (P < .001). This association was not attributable to the type of sensitization, the severity of sensitization, or atopic dermatitis during the first 2 years of life. In this group of children, 41.5% of all new cases of wheezing occurred among children with preceding allergic rhinitis.
Conclusions |
The first manifestation of allergic rhinitis occurs in preschool children in whom it is a predictor for subsequent wheezing onset. Preschool children with rhinitis might thus benefit from early assessment of allergic sensitization to identify the children at high risk of wheezing.
Le texte complet de cet article est disponible en PDF.Key words : Allergic rhinitis, birth cohort study, wheezing, allergic sensitization, risk factors
Abbreviations used : AHR, MAS, PARF, RR
Plan
| Supported by the German Ministry of Education and Research (BMBF), grant number 01 EE9406, and cofunded by an unrestricted educational grant from AstraZeneca Germany. M. K. R. was supported by a Marie Curie Actions research grant (MEST-CT-2005-020524-GALTRAIN). |
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| Disclosure of potential conflict of interest: M. J. Ege has received research grants from the European Union, the German Research Foundation (DFG), and the Behring-Rontgen Foundation. The rest of the authors have declared that they have no conflict of interest. |
Vol 126 - N° 6
P. 1170 - décembre 2010 Retour au numéro
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