Early childhood weight status in relation to asthma development in high-risk children - 07/08/11
, HuiChuan J. Lai, RD, PhD a, b, c, Kathy A. Roberg, RN, MS c, Ronald E. Gangnon, PhD b, d, Michael D. Evans, MS b, Elizabeth L. Anderson, BSN, MA c, Tressa E. Pappas, BS c, Douglas F. DaSilva, BS c, Christopher J. Tisler, MT c, Lisa P. Salazar, BS c, James E. Gern, MD c, e, Robert F. Lemanske, MD c, e
Reprint requests: Zhumin Zhang, PhD, University of Wisconsin–Madison, Department of Nutritional Sciences, 1415 Linden Dr, Madison, WI 53706-1562.Abstract |
Background |
Obesity has been proposed to be a risk factor for the development of childhood asthma.
Objective |
We sought to examine weight status from birth to age 5 years in relation to the occurrence of asthma at ages 6 and 8 years.
Methods |
Two hundred eighty-five full-term high-risk newborns with at least 1 asthmatic/atopic parent enrolled in the Childhood Origin of Asthma project were studied from birth to age 8 years. Overweight was defined by weight-for-length percentiles of greater than the 85th percentile before the age of 2 years and a body mass index percentile of greater than the 85th percentile at ages 2 to 5 years.
Results |
No significant concurrent association was found between overweight status and wheezing/asthma occurrence at each year of age. In contrast, longitudinal analyses revealed complex relationships between being overweight and asthma. Being overweight at age 1 year was associated with a decreased risk of asthma at age 6 (odds ratio [OR], 0.32; P = .02) and 8 (OR, 0.35; P = .04) years, as well as better lung function. However, being overweight beyond infancy was not associated with asthma occurrence. In fact, only children who were overweight at age 5 years but not at age 1 year had an increased risk of asthma at age 6 years (OR, 5.78; P = .05).
Conclusion |
In children genetically at high risk of asthma, being overweight at age 1 year was associated with a decreased risk of asthma and better lung function at ages 6 and 8 years. However, being overweight beyond infancy did not have any protective effect and even could confer a higher risk for asthma.
Le texte complet de cet article est disponible en PDF.Key words : Asthma, overweight, children, high-risk birth cohort
Abbreviations used : BMI, COAST, FEV0.5, FEV1, FVC
Plan
| Supported by National Institutes of Health grants R01 HL61879 and P01 HL70831 and US Department of Agriculture Hatch Multi-State Grant WIS01228. |
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| Disclosure of potential conflict of interest: R. F. Lemanske is a speaker for Merck, AstraZeneca, Doembecher Children’s Hospital, Washington University, Medicus Group, Park Nicolet Institute, the American College of Allergy, Asthma & Immunology, the LA Allergy Society, the Michigan Allergy/Asthma Society, the Medical College of Wisconsin, the Fund for Medical Research and Education (Detroit), Children’s Hospital of Minnesota, the Toronto Allergy Society, the American Academy of Allergy, Asthma & Immunology, Beaumont Hospital (Detroit), the University of Illinois, the Canadian Society of Allergy and Clinical Immunology, and New York Presbyterian; has consultant arrangements with AstraZeneca, Map Pharmaceuticals, Gray Consulting, Smith Research, the Merck Childhood Asthma Network, Novartis, Quintiles/Innovax, RC Horowitz & Co, and Scienomics; is an author for Up-to-Date; and is a textbook editor for Elsevier. The rest of the authors have declared that they have no conflict of interest. |
Vol 126 - N° 6
P. 1157-1162 - décembre 2010 Retour au numéro
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