The microbiology of chronic osteomyelitis: Prevalence of resistance to common empirical anti-microbial regimens - 07/08/11
, B.A. Atkins a, b, P. Bejon a, b, I. Byren a, b, D. Wyllie d, N.A. Athanasou e, A.R. Berendt a, b, M.A. McNally b
Corresponding author at: Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK. Tel.: +44 1865 857425; fax: +44 1865 857471.Summary |
Objectives |
This study describes the microbiological spectrum of chronic osteomyelitis and so guides the choice of empirical antibiotics for this condition.
Methods |
We performed a prospective review of a 166 prospective patient series of chronic osteomyelitis from Oxford, UK in which a standardised surgical sampling protocol was used.
Results |
Staphylococcus aureus was most commonly isolated (32%) amongst a wide range of organisms including gram negative bacilli, anaerobes and coagulase negative staphylococci. Low grade pathogens were not confined to patients with a history of metalwork, a high proportion of cases were polymicrobial (29%) and culture negative cases were common (28%). No clear predictors of causative organism could be established. Many isolates were found to be resistant to commonly used empirical anti-microbial regimens.
Conclusions |
The wide range of causative organisms and degree of resistance to commonly used anti-microbials supports the importance of extensive intra-operative sampling and provides important information to guide clinicians' choice of empirical antibiotics.
Le texte complet de cet article est disponible en PDF.Keywords : Osteomyelitis, Microbiology
Plan
Vol 60 - N° 5
P. 338-343 - mai 2010 Retour au numéro
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