Ten years experience of Salmonella infections in Cambridge, UK - 07/08/11
Corresponding author. Clinical Microbiology and Public Health Laboratory, Health Protection Agency, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QW, UK. Tel.: +44 1223 257055; fax: +44 1223 242775.Summary |
Objectives |
Review of all Salmonella infections diagnosed in the Cambridge area over 10 years.
Methods |
All Salmonella enterica isolated in the Clinical Microbiology Laboratory, Addenbrooke's Hospital between 1.1.1999 and 31.12.2008 were included. Patient demographics, serotype and additional relevant details (travel history, resistance-type, phage-type) were recorded.
Results |
1003 episodes of Salmonella gastroenteritis were confirmed by stool culture, representing 88 serotypes. Serotypes Enteritidis (59%), Typhimurium (4.7%), Virchow (2.6%), Newport (1.8%) and Braenderup (1.7%) were the 5 most common isolates. There were an additional 37 invasive Salmonella infections (32 blood cultures, 4 tissue samples, 1 CSF). 13/15 patients with Salmonella Typhi or Salmonella Paratyphi isolated from blood or faeces with an available travel history had returned from the Indian subcontinent. 8/10 S. Typhi or Paratyphi isolates tested had reduced susceptibility to fluoroquinolones (MIC≥0.125mg/L). 7/21 patients with non-typhoidal Salmonella bacteraemia were known to be immunosuppressed.
Conclusion |
This study describes Salmonella serotypes circulating within a defined geographical area over a decade. Prospective molecular analysis of isolates of S. enterica by multi-locus sequence typing (MLST) and single nucleotide polymorphism (SNP) detection will determine the geo-phylogenetic relationship of isolates within our region.
Le texte complet de cet article est disponible en PDF.Keywords : Salmonella enterica, Enteric fever, Typhoid fever, Paratyphoid fever, Gastroenteritis, Epidemiology, Fluoroquinolones, Antibiotic resistance
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Vol 60 - N° 1
P. 21-25 - janvier 2010 Retour au numéro
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