Circulating antibodies to endogenous erythropoietin and risk for HIV-1-related anemia - 07/08/11
, Theodore Kordossis a , Panayiotis D. Ziakas a , Athanasios N. Kontos a , Despina Kyriaki b , Nikolaos V. Sipsas a 
Corresponding author. Tel.: +30 210 7462643; fax: +30 22910 41777.Summary |
Objectives |
In a previous retrospective study we have shown that circulating antibodies to endogenous erythropoietin (anti-EPO) are associated with HIV-1-related anemia. The present longitudinal cohort study was conducted to examine the effect of anti-EPO on the risk of developing anemia over time.
Methods |
The study population consisted of 113 HIV-1 seropositive patients, who were screened for the presence of anti-EPO, with a mean±SD follow up of 105±40 months, for a total of 2190 visits. Anti-EPO were detected with an ELISA assay.
Results |
Anti-EPO were detected in 41% (46/113) at enrollment and 29% (320/1094) for all visits, and were associated with higher EPO levels for all visits (45.7±60.4 vs. 31.8±31.7IU/ml, p<0.001). After adjusting for other significant confounders, anti-EPO has been associated with increased risk of anemia both at enrollment (odds ratio [OR], 5.07; 95% confidence interval [CI], 1.25–20.49) as well as for all visits ([OR], 2.15; 95% [CI]: 1.29–3.56). During follow up, a decline in prevalence of both anti-EPO and anemia was observed as the percentage of patients receiving HAART was increasing.
Conclusions |
Anti-EPO are an independent risk factor for anemia in HIV-1-infected patients. HAART seems to reduce both anti-EPO and anemia prevalence.
Le texte complet de cet article est disponible en PDF.Keywords : HIV-1, Anemia, Erythropoietin, Autoantibodies
Plan
Vol 60 - N° 3
P. 238-243 - mars 2010 Retour au numéro
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