Associations between cardiovascular parameters and uteroplacental Doppler (blood) flow patterns during pregnancy in women with congenital heart disease: Rationale and design of the Zwangerschap bij Aangeboren Hartafwijking (ZAHARA) II study - 06/08/11
, Krystyna M. Sollie, MD b, k, Barbara J.M. Mulder, MD, PhD d, k, Monique W.M. de Laat, MD, PhD e, Jolien W. Roos-Hesselink, MD, PhD f, Arie P.J. van Dijk, MD, PhD g, Elly M.C.J. Wajon, MD h, Hubert W. Vliegen, MD, PhD i, Willem Drenthen, MD, PhD a, Hans L. Hillege, MD, PhD a, c, Jan G. Aarnoudse, MD, PhD b, Dirk J. van Veldhuisen, MD, PhD a, Petronella G. Pieper, MD, PhD a, ⁎ Résumé |
Background |
Previous research has shown that women with congenital heart disease (CHD) are more susceptible to cardiovascular, obstetric, and offspring events. The causative pathophysiologic mechanisms are incompletely understood. Inadequate uteroplacental circulation is an important denominator in adverse obstetric events and offspring outcome. The relation between cardiac function and uteroplacental perfusion has not been investigated in women with CHD. Moreover, the effects of physiologic changes on pregnancy-related events are unknown. In addition, long-term effects of pregnancy on cardiac function and exercise capacity are scarce.
Methods |
Zwangerschap bij Aangeboren Hartafwijking (ZAHARA) II, a prospective multicenter cohort study, investigates changes in and relations between cardiovascular parameters and uteroplacental Doppler flow patterns during pregnancy in women with CHD compared to matched healthy controls. The relation between cardiovascular parameters and uteroplacental Doppler flow patterns and the occurrence of cardiac, obstetric, and offspring events will be investigated. At 20 and 32 weeks of gestation, clinical, neurohumoral, and echocardiographic evaluation and fetal growth together with Doppler flow measurements in fetal and maternal circulation are performed. Maternal evaluation is repeated 1 year postpartum.
Implications |
By identifying the factors responsible for pregnancy-related events in women with CHD, risk stratification can be refined, which may lead to better pre-pregnancy counseling and eventually improve treatment of these women.
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| This study is supported by a grant from the Netherlands Heart Foundation (NHF) (2007B75). DJvV is clinically established investigator of the NHF (D97-017). The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the paper and its final contents. |
Vol 161 - N° 2
P. 269 - février 2011 Retour au numéro
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