Motion Corrected Cadence CPS Ultrasound for Quantifying Response to Vasoactive Drugs in a Rat Kidney Model - 06/08/11

Doi : 10.1016/j.urology.2009.01.086

Rachel E. Pollard ^a,⁎ , Paul A. Dayton ^b,^c, Katherine D. Watson ^b, Xiaowen Hu ^b, Ismayil M. Guracar ^d, Katherine W. Ferrara ^b
^a Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California
^b Department of Biomedical Engineering, University of California, Davis, CA
^c Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina
^d Siemens Medical Solutions, Ultrasound Division, Mountain View, California

^*Reprint requests: Rachel E. Pollard, D.M.V., Ph.D., Department of Surgical and Radiological Sciences, University of California, Davis School of Veterinary Medicine, Davis, California 95616

Résumé

Objective

To establish the ability of contrast-enhanced motion corrected cadence pulse sequencing (CPS) to detect changes in renal blood flow induced by vasoactive substances in rats.

Methods

Ultrasound contrast media was administered as a constant rate infusion into a phantom at a known rate and CPS data acquired. Rats were anesthetized and predrug CPS estimates of replenishment rate were made for the right kidney. Real-time motion correction was applied, and parametric images were generated from the CPS data. Group 1 rats (n = 7) were administered a vasodilator and group 2 rats (n = 3) were administered a vasoconstrictor. The CPS imaging of the kidney was repeated after ample time for drug effects to occur.

Results

Contrast CPS accurately estimated flow velocity in the phantom model. In addition, CPS defined statistically significant differences between pre- and postdrug blood flow in the renal medulla (vasodilator, P < .01; vasoconstrictor, P < .0001) and cortex (vasoconstrictor, P < .0001).

Conclusions

We conclude that motion-corrected CPS ultrasound provides real-time quantification of renal blood flow alterations and may prove useful for the assessment of blood flow in transplanted kidneys.

Le texte complet de cet article est disponible en PDF.