Does Histologic Subtype Affect Oncologic Outcomes After Nephron-sparing Surgery? - 06/08/11
Reprint requests: Pierre I. Karakiewicz, M.D., Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center (CHUM), 1058 Rue St. Denis, Montréal, QC H2X 3J4 CanadaRésumé |
Objectives |
To test whether renal cell carcinoma (RCC) histologic subtypes (HSs) affect cancer-specific mortality after nephron-sparing surgery (NSS). HSs are considered of prognostic value in RCC. For example, the papillary HS might confer a worse prognosis, and, at some centers, only radical nephrectomy is performed for the papillary HS.
Methods |
We used univariate and multivariate Cox regression models to study patients with Stage T1N0M0 RCC treated with NSS (n = 1205) from 1988 to 2004. The data were taken from 9 Surveillance, Epidemiology, and End Results registries.
Results |
At 36 months after NSS, the cancer-specific mortality rate was 97.8%, 100%, and 97.4% for a clear cell, chromophobe, and papillary RCC HS, respectively. On univariate and multivariate analyses, no statistically significant differences were recorded with regard to the HS.
Conclusions |
Despite the suggested more aggressive phenotype of the papillary HS, we found no difference among the papillary, chromophobe, and clear cell variants. Thus, the diagnosis of one HS vs another HS should not deter from the use of NSS when cancer-specific mortality is considered as an endpoint.
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| P. I. Karakiewicz was partially supported by the University of Montreal Health Center Urology Associates, Fonds de la Recherche en Santé du Quebec, the Department of Surgery, University of Montreal, and the University of Montreal Health Center Foundation; M. Crépel was partially supported by the Association Française d'urologie. |
Vol 74 - N° 4
P. 842-845 - octobre 2009 Retour au numéro
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