Airway smooth muscle as an immunomodulatory cell - 05/08/11
Corresponding author. Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, University of Pennsylvania, 125 South 31st Street, TRL Suite 1200, Philadelphia, PA 19104-3403, USA. Tel.: +1 215 573 9860; fax: +1 215 746 1224.Abstract |
Although pivotal in regulating bronchomotor tone in asthma, airway smooth muscle (ASM) also modulates airway inflammation in asthma. ASM myocytes secrete or express a wide array of immunomodulatory mediators in response to extracellular stimuli, and in chronic severe asthma, increases in ASM mass may also render the airway irreversibly obstructed. Although the mechanisms by which ASM secretes cytokines and chemokines are shared with those regulating immune cells, there exist unique ASM signaling pathways that may provide novel therapeutic targets. This review provides an overview of our current understanding of the proliferative as well as synthetic properties of ASM.
Le texte complet de cet article est disponible en PDF.Keywords : Synthetic function, Airway remodeling, Mesenchymal cells, Airway hyperresponsiveness, Hyperplasia, Hypertrophy
Plan
Vol 22 - N° 5
P. 353-359 - octobre 2009 Retour au numéro
Article précédent
- Airways smooth muscle: The next generation
- Alaina Ammit, Andrew J. Halayko, Stuart J. Hirst, Tom Murphy, Alastair Stewart
- The life and research of Ann Woolcock (1937–2001)
- Carol Armour
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