Muscle Physiology in Healthy Men and Women and Those with Metabolic Myopathies - 05/08/11

Doi : 10.1016/j.pmr.2008.10.011

Michaela C. Devries, BSc, MSc ^a, Mark A. Tarnopolsky, MD, PhD, FRCPC ^a,^b,^⁎
^a Pediatrics & Medicine, Division of Neurology, McMaster University, McMaster University Medical Center, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
^b Neurometabolic, Neuromuscular Clinic, McMaster University, 1200 Main Street West, HSC-2H26, Hamilton, ON, Canada L8N 3Z5

Corresponding author. Neurometabolic, Neuromuscular Clinic, McMaster University, 1200 Main Street West, HSC-2H26, Hamilton, ON, Canada L8N 3Z5.

Abstract

The relative contribution and source of the fuels used during endurance exercise is dependent on the intensity and the duration of the exercise. Much work has been done to investigate the potential performance-enhancing effect of manipulating training and dietary interventions in athletes, as well as the influence of gender. Studies show that even patients with metabolic myopathies may derive benefits that counter the age-associated loss of muscle mass and strength. This article gives an overview of these different impacts on endurance exercise, concluding with an examination of the metabolic myopathies that impair substrate metabolism in skeletal muscle and result in exercise intolerance.

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Keywords : Muscle physiology, Carbohydrates, Exercise, Fatigue

Plan

Carbohydrate oxidation during endurance exercise

Lipid oxidation during endurance exercise

Amino acid oxidation during endurance exercise

Exercise intensity and duration impact substrate selection during endurance exercise

Effect of endurance training on substrate selection during endurance exercise

Effect of sex on substrate selection during endurance exercise

Effect of diet on substrate selection during endurance exercise

Carbohydrate Loading

Carbohydrate Drinks During Exercise

High Fat Diets

Exercise metabolism and nutrition for inborn errors of metabolism affecting skeletal muscle

Glycogen Storage Disease

Fatty Acid Oxidation Defects

Mitochondrial Disorders

	This article originally appeared in Neurologic Clinics, Volume 26, Issue 1.
	This work was supported by National Sciences and Engineering Research Council of Canada, Canadian Institutes of Health Research, and donations from Warren Lammert and Kathy Corkins and Giant Tiger Stores.