Plasma total cysteine and total homocysteine and risk of myocardial infarction in women: A prospective study - 05/08/11
, Jing Ma, MD, PhD b, Stephanie E. Chiuve, ScD c, Meir J. Stampfer, MD, DrPH a, b, c, d, Jacob Selhub, PhD e, JoAnn E. Manson, MD, DrPH a, b, d, Eric B. Rimm, ScD a, b, cRésumé |
Background |
Cysteine is a glutathione precursor, but is also a homocysteine byproduct. We prospectively evaluated relationships between fasting plasma concentrations of total cysteine and total homocysteine, and subsequent myocardial infarction (MI) in women.
Methods |
Among 32,826 women who provided blood samples between 1989 and 1990, 239 were diagnosed with incident MI after blood collection, but before July 1998. Of these women, 144 had provided a postfast sample. We matched controls to cases 2:1 by age, cigarette smoking status, and month and fasting status at the time of blood collection. We used conditional logistic regression to adjust for confounding.
Results |
Fasting total cysteine was positively related to MI risk in matching factor-adjusted analyses (rate ratio [RR] for highest vs lowest quartile 3.50 [95% CI 1.44-8.52]). However, after controlling for conventional risk factors of MI, it was not independently associated with risk (RR for highest vs lowest quartile 1.32 [95% CI 0.42-4.12, P trend = .10]). Fasting homocysteine was positively associated with MI risk; the multivariable adjusted RR for the highest versus the lowest quartile was 3.37 (95% CI 1.30-8.70, P trend = .014).
Conclusions |
Fasting plasma concentration of total homocysteine, but not total cysteine, was positively associated with MI risk.
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Vol 159 - N° 4
P. 599-604 - avril 2010 Retour au numéro
Article précédent
- QRS prolongation in patients with acute coronary syndromes
- Fahad Baslaib, Salem Alkaabi, Andrew T. Yan, Raymond T. Yan, Paul Dorian, Kumaraswamy Nanthakumar, Amparo Casanova, Shaun G. Goodman, for the Canadian Acute Coronary Syndrome Registry Investigators d
- Evaluation of left ventricular ejection fraction in non–ST-segment elevation acute coronary syndromes and its relationship to treatment
- Sean Jedrzkiewicz, Shaun G. Goodman, Raymond T. Yan, Francois R. Grondin, Richard Gallo, Robert C. Welsh, Kevin Lai, Thao Huynh, Andrew T. Yan, on behalf of the Canadian Acute Coronary Syndrome I and II Registries, the Canadian Global Registry of Acute Coronary Events (GRACE/GRACE2), and the Canadian Registry of Acute Coronary Events (CANRACE) Investigators
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