6-Mercaptopurine complexes with silver and gold ions: Anti-tuberculosis and anti-cancer activities - 03/08/11
, Antonio Carlos Massabni b, Guilherme Alves Pereira a, Clarice Queico Fujimura Leite c, Fernando Rogério Pavan c, Renata Sesti-Costa d, Tassiele Andréa Heinrich d, Claudio M. Costa-Neto d
Corresponding author. Tel.: +55 32 3229-3310; fax: +55 32 3229-3302.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 5 |
| Iconographies | 5 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Synthesis, characterization and biological studies of silver and gold complexes with 6-mercaptopurine (H2MP) are described. The Ag(I) and Au(I) complexes with HMP-, AgHMP and AuIHMP, were obtained by mixing an acidified H2MP aqueous solution with an equimolar aqueous solution of AgNO3 or Au(CN)2. The Au(III) complex with HMP-, AuIIIHMP, was obtained by adding an aqueous solution of K(AuCl4) to an acidified H2MP aqueous solution (1:1 molar ratio) and the final solution was acidified with HCl to pH=1.0. The Au(III)MP complex, KAu(MP)2, was obtained by adding an aqueous solution of K(AuCl4) to a basic H2MP solution (M:L - 1:2 molar ratio). Formulas for the complexes are: (Ag[C5H3N4S])*½H2O for AgHMP, (Au[C5H3N4S]) for AuIHMP, (Au[C5H3N4S][Cl]2)*2H2O for AuIIIHMP and K(Au[C5H2N4S]2)·2H2O for KAu(MP)2. The AuIHMP and KAu(MP)2 complexes decreased cell viability of HeLa cancer cells in vitro. The IC50 values for AuIHMP and KAu(MP)2 are 3.0 and 30.0 μM, respectively. Anti-M.tuberculosis assays showed a MIC value of 2.24 μM for AuIHMP and 5.12 μM for free MP while AgHMP is active at the concentration 93.2 μM.
Le texte complet de cet article est disponible en PDF.Keywords : Silver, Gold, Mercaptopurine, Tuberculosis, Arthritis, Cancer
Plan
Vol 65 - N° 5
P. 334-338 - août 2011 Retour au numéro
Article précédent
- Auto-inhibition of verapamil metabolism in rat hepatocytes of gel entrapment culture
- Jian Yin, Qin Meng, Xiaomei Dong
- Interleukin 1 receptor antagonist reduces lethality and intestinal toxicity of 5-Fluorouracil in a mouse mucositis model
- Zhenqian Wu, Xiaodong Han, Shenyin Qin, Qi Zheng, Zhigang Wang, Di Xiang, Jing Zhang, Huili Lu, Mingyuan Wu, Shunying Zhu, Yan Yu, Yu Wang, Wei Han
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?