Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids - 03/08/11
Résumé |
Objective |
Maternal immunization with oxidized low-density lipoprotein prior to pregnancy prevents pathogenic in utero programming by gestational hypercholesterolemia, but it is unknown whether gestational hypercholesterolemia and maternal immunization affect similar pathways.
Study Design |
A lipidomic approach was used for unbiased plasma eicosanoid profiling in adult offspring of immunized and nonimmunized normocholesterolemic or hypercholesterolemic rabbit mothers.
Results |
Gestational hypercholesterolemia was associated with increased levels of some eicosanoids formed by the cyclooxygenase and 12-lipoxygenase pathways only (including thromboxane B2, prostaglandin [PG] F2⍺, PGE2, and PGD2). Immunization of hypercholesterolemic or normocholesterolemic mothers reduced 9 of 14 eicosanoids of the cyclooxygenase pathway, 21 of 23 eicosanoids of the 5- and 12-lipoxygenase pathways (eg, 5-hydroxyeicosatetraenoic acid, hepoxilin B3, 12-hydroxyeicosatetraenoic acid), 8 of 19 eicosanoids of the cytochrome P-450 pathway, and all metabolites of the nonenzymatic pathway.
Conclusion |
Maternal immunization not only counteracts in utero programming by gestational hypercholesterolemia but reduces a broad range of eicosanoid modulators of immunity and inflammation in offspring.
Le texte complet de cet article est disponible en PDF.Key words : cardiovascular disease, developmental programming, eicosanoids, immunization, inflammation, rabbits
Plan
| This study was supported by National Institutes of Health (NIH) Grants HL-067792 and HL-089559 (Dr Palinski), Ellison Medical Foundation senior scholar award AG-SS 1851-07 (Dr Palinski), and the NIH LIPID MAPS large-scale collaborative Grant GM069338 (Drs Dennis and Quehenberger). |
|
| Reprints not available from the authors. |
|
| Cite this article as: Quehenberger O, Yamashita T, Armando AM, et al. Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids. Am J Obstet Gynecol 2011;205:156.e15-25. |
Vol 205 - N° 2
P. 156.e15-156.e25 - août 2011 Retour au numéro
Article précédent
- Placental protein 13 (PP13/galectin-13) undergoes lipid raft-associated subcellular redistribution in the syncytiotrophoblast in preterm preeclampsia and HELLP syndrome
- Andrea Balogh, Judit Pozsgay, János Matkó, Zhong Dong, Chong Jai Kim, Tibor Várkonyi, Marei Sammar, János Rigó, Hamutal Meiri, Roberto Romero, Zoltán Papp, Nándor Gábor Than
- Human amnion epithelial cells as a treatment for inflammation-induced fetal lung injury in sheep
- Patricia Vosdoganes, Ryan J. Hodges, Rebecca Lim, Alana J. Westover, Rutu Y. Acharya, Euan M. Wallace, Timothy J.M. Moss
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?