Contribution of different local vascular responses to mid-gestational vasodilation - 03/08/11
, Jeanne Pertijs b, Alfons Wouterse, B AS b, Rob Hermsen c, Fred C.G.J. Sweep, PhD c, Frederik K. Lotgering, MD, PhD a, Paul Smits, MD, PhD b, Marc E.A. Spaanderman, MD, PhD a
Reprints: Joris van Drongelen, MD, MSc, Department of Obstetrics and Gynecology 791, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The NetherlandsRésumé |
Objective |
At-term pregnancy-induced vasodilation is the resultant of endothelium-dependent vasodilation, decreased myogenic reactivity, increased compliance, and reduced sensitivity to vasoconstrictor agents. We hypothesized that these vascular changes are already present at mid-gestation.
Study Design |
In 20 mid-pregnant and 20 nonpregnant Wistar Hannover rats, we measured vascular responses of isolated mesenteric arteries and kidney.
Results |
In the pregnant rats compared with the nonpregnant rats, mesenteric flow-mediated vasodilation and renal perfusion flow increased 1.52-fold (from 47 ± 5 to 31 ± 4 μL/min) and 1.13-fold (from 12.8 ± 0.1 to 14.4 ± 0.1 mL/min), respectively. Nitric oxide inhibition reduced mesenteric flow-mediated vasodilation to a similar extent in the pregnant and nonpregnant rats; it completely blocked the pregnancy-induced increase in renal perfusion flow. Pregnancy did not change mesenteric artery sensitivity to phenylephrine, myogenic reactivity, nor vascular compliance.
Conclusion |
At mid-gestation, alterations in rat mesenteric vascular tone depend primarily on flow-mediated endothelium-dependent changes and not on changes in ⍺-adrenergic vasoconstrictor sensitivity, myogenic reactivity, or vascular compliance.
Le texte complet de cet article est disponible en PDF.Key words : flow-mediated vasodilation, mid-pregnancy, myogenic reactivity, phenylephrine, vascular compliance
Plan
| Authorship and contribution to the article is limited to the 8 authors indicated. There was no outside funding or technical assistance with the production of this article. |
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| Cite this article as: van Drongelen J, Pertijs J, Wouterse A. et al. Contribution of different local vascular responses to mid-gestational vasodilation. Am J Obstet Gynecol 2011;205:155.e12-17. |
Vol 205 - N° 2
P. 155.e12-155.e17 - août 2011 Retour au numéro
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