Exenteration as a primary treatment for locally advanced cervical cancer: long-term results and prognostic factors - 03/08/11
, Bjoern Lampe, MD
Reprints: Dirk Michael Forner, MD, Sana Klinikum, Department of Obstetrics and Gynecology, Burger Strasse 211, D-42859 Remscheid, GermanyRésumé |
Objective |
Whereas pelvic exenteration is an established therapy for the treatment of recurrent cervical carcinoma, it is not often performed for primary locally advanced cervical cancer (LACC).
Study Design |
This retrospective study analyzed survival data and prognostic factors of 35 patients with LACC who were treated by pelvic exenteration.
Results |
After surgery, 33 patients (97%) were macroscopically free of tumor. In 20 patients, pelvic lymph nodes (LN) were involved, and in 6 of these, metastatic tissue had reached the paraaortal nodes. Overall, the patients' mean 5 year survival was 43%, and the median survival time was 30 months; these values ranged from 15% to 70% and from 15 to 44 months, respectively, depending on LN involvement (P = .006). Pelvic LN involvement was the only significant factor for overall survival found in the multivariate analysis (P = .02).
Conclusion |
In LACC with free LNs and no distant metastases, pelvic exenteration has good long-term results.
Le texte complet de cet article est disponible en PDF.Key words : genital neoplasm, pelvic exenteration, survival, urinary reservoirs, uterine cervical neoplasm
Plan
| Cite this article as: Forner DM; Lampe B. Exenteration as a primary treatment for locally advanced cervical cancer: long-term results and prognostic factors. Am J Obstet Gynecol 2011;205:148.e1-6. |
Vol 205 - N° 2
P. 148.e1-148.e6 - août 2011 Retour au numéro
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