C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R Study - 03/08/11
Reprints: Vincent W. V. Jaddoe, MD, PhD, the Generation R Study Group (AE-006), Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The NetherlandsRésumé |
Objective |
We sought to examine the associations of maternal C-reactive protein (CRP) levels with fetal growth and the risks of neonatal complications.
Study Design |
CRP levels were measured in early pregnancy in 6016 women. Main outcome measures were fetal growth in each trimester and neonatal complications.
Results |
As compared to the reference group (CRP levels <5 mg/L), elevated maternal CRP levels (≥25 mg/L) were associated with lower estimated fetal weight in third trimester and lower weight at birth (differences: −29 g, 95% confidence interval [CI], −58 to 0 and −128 g, 95% CI, −195 to −60, respectively). Elevated maternal CRP levels were also associated with an increased risk of a small size for gestational age in the offspring (adjusted odds ratio, 2.94; 95% CI, 1.61–5.36).
Conclusion |
Maternal CRP levels in early pregnancy are associated with fetal growth restriction and increased risks of neonatal complications.
Le texte complet de cet article est disponible en PDF.Key words : cohort studies, C-reactive protein, fetal growth, inflammation, neonatal complications, pregnancy
Plan
| Cite this article as: Ernst GDS, de Jonge LL, Hofman A, et al. C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R Study. Am J Obstet Gynecol 2011;205:132.e1-8. |
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| The first 2 authors contributed equally to this article. |
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| The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and the Faculty of Social Sciences at the Erasmus University, Rotterdam; the Municipal Health Service, Rotterdam area; and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (Star-MDC), Rotterdam. |
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| The general design of the Generation R Study was made possible by financial support from the Erasmus Medical Center, Rotterdam; Erasmus University, Rotterdam; the Dutch Ministry of Health, Welfare and Sport; and The Netherlands Organization for Health Research and Development (ZonMw). Further support for the present study was obtained from the Dutch Heart Foundation (2008B114) and Abbott Diagnostics B.V., Hoofddorp, The Netherlands. Dr Jaddoe received additional grants from The Netherlands Organization for Health Research and Development (ZonMw 90700303, 916.10159). |
Vol 205 - N° 2
P. 132.e1-132.e12 - août 2011 Retour au numéro
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