Clinical and inflammatory markers in amniotic fluid as predictors of adverse outcomes in preterm premature rupture of membranes - 03/08/11
, Mónica Martínez-Terrón, MD a, Aleix Navarro-Sastre, MD b, d, e, Jordi Bosch, MD c, Xavier Filella, MD b, Eduard Gratacós, MD a, d, e
Reprints: Montse Palacio, MD, Prematurity Unit, Department of Maternal-Fetal Medicine, Hospital Clinic, Sabino de Arana 1, Barcelona 08028, Catalonia, SpainRésumé |
Objective |
We sought to evaluate gestational age, cervical length, amniotic fluid interleukin (IL)-6, and selected proteomic biomarkers as independent predictors of adverse outcome in preterm premature rupture of membranes (PPROM).
Study Design |
This was a prospective cohort study of 65 consecutive women with PPROM (20.0-34.6 weeks). Gestational age, cervical length, amniotic fluid IL-6, and proteomic biomarkers (calgranulins A and C, and neutrophil defensins 1 and 2) were evaluated at diagnosis. The predictive value for intraamniotic infection and neonatal composite morbidity was calculated by logistic regression.
Results |
Proteomic biomarkers were independent predictors of intraamniotic infection (odds ratio, 22.1; P = .011) and neonatal composite morbidity (odds ratio, 17.6; P = .02). With the exception of a trend between gestational age and neonatal morbidity (P = .054), none of the other parameters were independent predictors of outcome measures.
Conclusion |
Selected proteomic biomarkers were the only independent predictors of adverse outcomes in PPROM. Contrary to what is reported in preterm labor with intact membranes, gestational age, cervical length, and IL-6 were not.
Le texte complet de cet article est disponible en PDF.Key words : cervical length, gestational age at membrane rupture, interleukin-6, intraamniotic infection, selected proteomic biomarkers
Plan
| Cite this article as: Cobo T, Palacio M, Martínez-Terrón M, et al. Clinical and inflammatory markers in amniotic fluid as predictors of adverse outcomes in preterm premature rupture of membranes. Am J Obstet Gynecol 2011;205:126.e1-8. |
Vol 205 - N° 2
P. 126.e1-126.e8 - août 2011 Retour au numéro
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