Placental infarction identified by macroscopic examination and risk of cerebral palsy in infants at 35 weeks of gestational age and over - 03/08/11
Résumé |
Objective |
We sought to investigate whether placental infarction determined by macroscopic examination was associated with risk of cerebral palsy (CP).
Study Design |
This was a population-based study of macroscopic placental infarcts in singletons >35 weeks' gestational age, in 158 perinatal deaths, 445 infants with CP, and 491 controls matched with CP cases for gestational age.
Results |
Placental infarcts were recorded in 2.0% of controls, 4.4% of deaths (relative risk [RR], 2.2; 95% confidence interval [CI], 0.8–5.6]), 5.2% of infants with CP (P < .05, RR, 2.5; 95% CI, 1.2–5.3), and 8.4% with spastic quadriplegic CP (P = .0026; RR, 4.4; 95% CI, 1.8–10.6). In children with CP, unlike controls, placental infarction was associated with reduced fetal growth, older maternal age, more prior miscarriages, and poor neonatal condition, but not with maternal preeclampsia.
Conclusion |
Placental infarction identified by macroscopic examination was associated with increased risk of CP and the CP subtype, spastic quadriplegic CP. Antecedents of placental infarction differed in children with CP compared with control children.
Le texte complet de cet article est disponible en PDF.Key words : infarction, growth restriction, placenta, preeclampsia
Plan
| Reprints not available from the authors. |
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| Support was provided by the National Health and Medical Research Council of Australia under program Grant 353514, approved by the Princess Margaret Hospital/King Edward Memorial Hospital Ethics Committee, the Confidentiality of Health Information Committee of the Western Australia Department of Health, and individual hospital and regional ethics committees, where required. |
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| Cite this article as: Blair E, de Groot J, Nelson KB. Placental infarction identified by macroscopic examination and risk of cerebral palsy in infants at 35 weeks of gestational age and over. Am J Obstet Gynecol 2011;205:124.e1-7. |
Vol 205 - N° 2
P. 124.e1-124.e7 - août 2011 Retour au numéro
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