Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis - 02/08/11
Corresponding author. Tel./fax: +86 10 51520496.Summary |
Objectives |
T cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) plays an important role in regulating T cell responses and induction of peripheral tolerance. In this study, the association of Tim-3 with active pulmonary tuberculosis (TB) was investigated.
Methods |
Tim-3 expression on CD8 T cells and its influence on production of effector molecules and proliferation of CD8 T cells were examined.
Results |
Pulmonary TB patients had significantly elevated Tim-3 expression on total CD8 T cells (P < 0.0001) and on antigen-specific CD8 T cells (P = 0.0028) compared with tuberculin-positive healthy controls. The expression of Tim-3 on CD8 T cells was significantly higher in smear/culture-positive TB patients than smear/culture-negative TB patients (P < 0.0001). Tim-3 expressing CD8 T cells had reduced production of IFN-γ, decreased degranulation and lower proliferation in response to Mycobacterium tuberculosis antigen stimulation. Blocking of Tim-3 signaling led to significantly increased production of IFN-γ.
Conclusions |
The elevated expression of Tim-3 on CD8 T cells correlates with functional defects of CD8 T cells and disease severity of pulmonary TB.
Le texte complet de cet article est disponible en PDF.Keywords : Tuberculosis, Tim-3, CD8 T cells, Functional defects
Plan
Vol 62 - N° 4
P. 292-300 - avril 2011 Retour au numéro
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