Low Levels of Asymmetric Dimethylarginine in Children with Diabetes Mellitus Type I Compared with Healthy Children - 02/08/11
, Burkhard Simma, MD b, Dieter Mayr, MD a, Adolf Mühl, PhD c, Birgit Rami, MD d, Edith Schober, MD d, Hanno Ulmer, PhD e, Ulrike Zanier, MD f, Olaf A. Bodamer, MD g
Reprint requests: Martina Huemer, MD, Department of Pediatrics, Landeskrankenhaus Bregenz, Carl Pedenz Str 2, 6900 Bregenz, Austria.Abstract |
Objective |
Although high levels of asymmetric dimethylarginine (ADMA) are associated with an increased risk for vasculopathy in adults, elevated ADMA concentrations also have been found in healthy young children. Patients with diabetes mellitus type 1 (DM1) are at risk for vasculopathy, and because the function of ADMA in the development of vascular symptoms is incompletely understood, we investigated ADMA concentrations in pediatric patients with DM1 compared with healthy age- and sex-matched individuals.
Study design |
This cross-sectional study included 85 pediatric patients with DM1 and 89 age- and sex-matched healthy controls.
Results |
ADMA concentrations were significantly lower in the patients with DM1 and were inversely correlated with hemoglobin A1c concentrations.
Conclusions |
Besides its vasoprotective function, nitric oxide itself may exert oxidative stress by generating free radicals. In these circumstances, ADMA would protect the system from nitric oxide overproduction and perpetuation of oxidative stress. This theory is supported by the physiologically higher ADMA concentrations in healthy children. Thus, low ADMA concentrations in children with DM1 may be an indicator of impaired protection against oxidative stress.
Le texte complet de cet article est disponible en PDF.Mots-clés : ADMA, BP, BMI, DDAH, DM1, HDL, HbA1c, NO, NOS, tHcy
Plan
| Supported by the Federal Government of Vorarlberg, Austria. The authors declare no conflicts of interest. |
Vol 158 - N° 4
P. 602 - avril 2011 Retour au numéro
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