A Common Variant in the PNPLA3 Gene is a Risk Factor for Non-Alcoholic Fatty Liver Disease in Obese Taiwanese Children - 02/08/11
Reprint requests: Yen-Hsuan Ni, MD, PhD, Department of Pediatrics, National Taiwan University Hospital, 8 Chung-Shan South Road, Taipei, Taiwan.Abstract |
Objective |
To test the hypothesis that the presence of the PNPLA3 rs738409 G allele would increase the susceptibility of non-alcoholic fatty liver disease (NAFLD) in obese Taiwanese children.
Study design |
A total of 520 obese children aged 6-18 years were recruited. Their PNPLA3 rs738409 genotypes—CC, CG, or GG—were detected by the 5’-nuclease assay. The effects of the PNPLA3 rs738409 G allele on pediatric NAFLD were evaluated based on liver ultrasonography findings and mean serum alanine aminotransferase levels in these children.
Results |
NAFLD was present in 19.6% of the obese children. In comparison to the subjects with CC alleles, the risk of NAFLD was increased by 2.96-fold (95% CI, 1.57 to 5.59, P = .0008) in the subjects with CG alleles and by 5.84-fold (95% CI, 2.59 to 13.16; P < .0001) in those with GG alleles. Variant PNPLA3 rs738409 genotypes were associated with increases in mean serum alanine aminotransferase level of 4.77 IU/L (P = .0435) in subjects with CG alleles and of 10.86 IU/L (P < .0001) in those with GG alleles compared with subjects with CC alleles.
Conclusions |
The variant PNPLA3 rs738409 genotypes increased the risk of NAFLD in our population of obese Taiwanese children. The effect of the G allele on pediatric NAFLD followed a dominant genetic model.
Le texte complet de cet article est disponible en PDF.Mots-clés : ALT, AST, BMI, HOMA-IR, NAFLD, PNPLA3, SNP
Plan
| Supported by Far Eastern Memorial Hospital (Grants FEMH-95-C-020 and FEMH-97-C-011) and the National Science Council of Taiwan (Grant NSC-98-2628-B-002-006-MY3). The authors declare no conflicts of interest. |
Vol 158 - N° 5
P. 740-744 - mai 2011 Retour au numéro
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