A study of histologic and immunophenotypical staining patterns in cutaneous lymphoid hyperplasia - 28/07/11
, Khozayma Khamaysi, MD b, Ziad Khamaysi, MD a, Yehudit Ben Arie, MD b
Reprint requests: Reuven Bergman, MD, Department of Dermatology, Rambam Medical Center, Haifa, Israel.Abstract |
Background |
Cutaneous lymphoid hyperplasia (CLH) is generally classified according to clinicopathologic entities or put into broad spectrums of B-cell or T-cell predominance or co-dominance.
Objective |
We sought to discern histologic features and immunohistochemical staining patterns in CLH that may form a basis for a histologic classification system.
Methods |
We studied the clinical, histologic, immunophenotypical, and molecular characteristics of 24 consecutive patients with CLH.
Results |
The 24 cases were classified according to characteristic histologic features and immunophenotypical staining patterns as follows: presence of germinal center (GC) cell clusters forming well-defined lymphoid follicles (n = 10); presence of clusters of GC cell clusters not forming well-defined lymphoid follicles (n = 6); persistent arthropod assault type CLH (n = 1); CLH with a prominent histiocytic component (n = 4); and CLH without specific histologic and immunophenotypical features, that is, nonspecific mixed T-cell and B-cell CLH (n = 3). Most of the CLH cases did not demonstrate clonal T-cell receptor and/or immunoglobulin heavy chain gene rearrangements except for 3 cases in which the long-term follow-up was uneventful.
Limitations |
There were a limited number of cases in our study.
Conclusions |
A classification based on characteristic histologic features and immunophenotypical staining patterns, along with pertinent clinical and molecular data, may enhance the diagnosis of CLH.
Le texte complet de cet article est disponible en PDF.Key words : classification, clinical, cutaneous, histology, hyperplasia, immunophenotyping, lymphoid, molecular, patterns
Abbreviations used : CBCL, CLH, FCCL, GC, K, L, PCR, PSL, TCR
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 65 - N° 1
P. 112-124 - juillet 2011 Retour au numéro
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