Solar urticaria treated with intravenous immunoglobulins - 28/07/11
, Christophe Bedane, MD b, Annie Bonnevalle, MD c, Pierre Thomas, MD c, Jean-Louis Peyron, MD d, Bernard Rouchouse, MD e, Frederic Cambazard, MD e, Michel Jeanmougin, MD f, Manuelle Viguier, MD f
Correspondence to: Henri Adamski, MD, Service de Dermatologie, CHU Pontchaillou, Rue Henri Le Guilloux 35033 Rennes, France.Abstract |
Background |
Solar urticaria (SU) is a rare idiopathic photodermatosis induced immediately after sun exposure. This disorder may considerably restrict normal daily life and management is extremely difficult when treatment with oral H1 antihistamines and sun avoidance are ineffective.
Objective |
We sought to report the effectiveness of intravenous immunoglobulins (IVIG) in severe SU.
Methods |
We performed a retrospective multicentric study via the mailing of a questionnaire to the French photodermatology units to analyze all cases of patients with SU who were treated with IVIG.
Results |
Seven patients (5 women) with a mean age of 40 years (range 32-55 years) and a mean disease duration of 5 years (range 2-10 years) received IVIG. The administration schedule differed from one patient to another: 1.4 to 2.5 g/kg were infused over 2 to 5 days. Five of 7 patients obtained a complete remission. The number of courses necessary to obtain clinical remission varied from 1 to 3 courses. Complete remission was maintained during 4 to more than 12 months but antihistamines were still required. In one case, psoralen plus ultraviolet A photochemotherapy was administered.
Limitations |
Retrospective study design, limited number of patients, and variations in the IVIG administration schedule could limit the interpretation of the results.
Conclusion |
Our case series suggests a beneficial effect of IVIG in severe SU but additional prospective trials including a larger number of patients are needed to demonstrate the effectiveness of IVIG and to specify the optimal modalities of their administration in this disease.
Le texte complet de cet article est disponible en PDF.Key words : intravenous immunoglobulins, solar urticaria
Abbreviations used : IVIG, MUD, SFPD, SU, UV
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
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| Reprints not available from the authors. |
Vol 65 - N° 2
P. 336-340 - août 2011 Retour au numéro
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