4-aminoquinoline analogues and its platinum (II) complexes as antimalarial agents - 16/07/11
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Abstract |
The high incidence of malaria and drug-resistant strains of Plasmodium have turned this disease into a problem of major health importance. One of the approaches used to control it is to search for new antimalarial agents, such as quinoline derivates. This class of compounds composes a broad group of antimalarial agents, which are largely employed, and inhibits the formation of β-haematin (malaria pigment), which is lethal to the parasite. More specifically, 4-aminoquinoline derivates represent potential sources of antimalarials, as the example of chloroquine, the most used antimalarial worldwide. In order to assess antimalarial activity, 12 4-aminoquinoline derived drugs were obtained and some of these derivatives were used to obtain platinum complexes platinum (II). These compounds were tested in vivo in a murine model and revealed remarkable inhibition of parasite multiplication values, whose majority ranged from 50 to 80%. In addition they were not cytotoxic. Thus, they may be object of further research for new antimalarial agents.
Le texte complet de cet article est disponible en PDF.Keywords : Antimalarial activity, Plasmodium berghei, Quinoline, Platinum (II) complexes
Plan
Vol 65 - N° 4
P. 313-316 - juillet 2011 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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