259 Association of rs 2781666 G/T polymorphism of arginase 1 gene with myocardial infarction in the Tunisian population - 07/07/11
Résumé |
Introduction |
Arginase I (ARG I) is the final enzyme of the urea cycle that converts L-arginine to urea and ornithine. Emerging evidence have identified ARG I as a critical regulator for nitric oxide (NO) production via nitric oxide synthase (NOS).
Therefore upregulation of ARG I inhibit NOS-mediated NO and may contribute to endothelial dysfunction. In addition, pathophysiological role of ARG I on vascular disease have been extensively documented, and some recent studies support a role for ARG I in the development and complications of coronary artery disease (CAD). The aim of the present study is to investigate the possible association between rs 2781666 G/T polymorphism of ARG I gene and myocardial infarction (MI) in the Tunisian population.
Methods |
In a case-control study, a total of 321 patients with MI and 436 controls were included. The rs 2781666 G/T polymorphism of ARG I was determined by PCR-RFLP analysis.
Results |
Patients with MI had significantly higher frequency of TT genotype compared to controls (10.3% vs 6.7%; OR (95% CI), 2.05 (1.19 – 3.52), p = 0.009). The MI patients showed higher frequency of T allele compared to the controls (0.32 vs 0.23, OR (95% CI), 1.58(1.25 – 2.00), p<0.001). The association between rs 2781666 G/T polymorphism of ARG I gene and MI was no longer significant after adjustment for other well established risk factors.
Conclusion |
Our results revealed a significant but not independent association between rs2781666 G/T polymorphism of ARG I gene and (MI) in the Tunisian population.
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Vol 3 - N° 1
P. 85 - janvier 2011 Retour au numéro
Article précédent
- 258 C(-260)T polymorphism in the promoter of CD 14 gene is not associated with myocardial infarction in the tunisian population
- Riadh Jemaa, Yousra Sediri, Amani Kallel, Mhammed Sami Mourali, Moncef Feki, Monia Elasmi, Sameh Haj-Taeib, Haifa Sanhaji, Rachid Mechmeche, Naziha Kaabachi
- 260 Lack of association between the −420C>G genetic variant in the resistin locus and myocardial infarction in the Tunisian population
- Amani Kallel, Yosra Sédiri, Mhammed Sami Mourali, Monia Elasmi, Moncef Feki, Sameh Haj Taïeb, Souheil Omar, Haifa Sanhaji, Rachid Mechmeche, Riadh Jemaa, Naziha Kaabachi
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