The multicenter observational Generation MVP^TM study included 224 patients aged 77 +/– 10 years (men: 53%) implanted for sinus dysfunction (SD) or brady-tachy syndrome (SBT) (n=116) or atrio-ventricular block (AVB) (n=108). Programming function MVP^TM has been left to the discretion of the physician. Percentage of ventricular pacing and percentage of patients with paroxystic or persistent atrial arrhythmias was assessed at 9 months on average according to the indication of pacing and the state of programming function MVP^TM.

Percentage of ventricular pacing at 9 months is significantly lower for the 2 groups of indication for patients with MVP^TM function activated [On] compared with patients without function MVP^TM [Off]. Comparisons groups were made by the Mood’s median test.

Percentage of patients with atrial arrhythmias at 9 months was significantly lower when the MVP^TM function is programmed to [On] only in the AVB group.

In this study in current practice, at 9 months follow-up programming function MVP^TM is associated with a significant decrease of ventricular pacing for indications of SD-BTS and AV block. Moreover programming function MVP^TM is associated with a significant decrease of percentage of patients with atrial arrhythmias for AVB indications.
IndicationSD – BTS (n = 116)AVB (n = 108)MVPOffpMVPOnMVPOffpMVPOnNumber of pts19973969% VP79%< 0.0011%99%< 0.00115%médian1ier- 3ième Quart13.5 – 99.60.3 – 5.699 – 1000.4 – 75.6% pts in AA26%NS19%23%< 0.056%