Factors influencing depression endpoints research (FINDER): Study design and population characteristics - 28/05/11

Doi : 10.1016/j.eurpsy.2007.10.002

Ana Garcia-Cebrian ^a,^{^{2
Tel.: +44 1276 483028 (office); fax: +44 (0) 1276 483192.}} , Michael Bauer ^b,^⁎ , Angel L. Montejo ^c,^{^{3
Tel.: +34 923 12 65 96/97 (office); fax: +34 923 26 54 82.}} , Nicolas Dantchev ^d,^{^{4
Tel.: +33 142 34 84 35 (office); fax: +33 142 34 84 33.}} , Koen Demyttenaere ^e,^{^{5
Tel.: +32 163 48705 (office); fax: +32 163 48700.}} , Paul Gandhi ^a,^{^{1
Dr Paul Gandhi was employed by Eli Lilly and Company Limited, Basingstoke, UK at the time the research was performed.}}, Luigi Grassi ^f,^{^{6
Tel.: +39 0532 236 409 (office); fax: +39 0532 212240.}} , Brigitta U. Monz ^g,^{^{7
Tel.: +49 6132 779 3362 (office); fax: +49 6132 774233.}} , David G.S. Perahia ^a,^h,^{^{8
Tel.: +44 1276 483755 (office); fax: +44 (0) 1276 483711.},}^{^{9
Tel.: +44 20 8746 8733; fax: +44 (0) 20 8746 8711.}} , Deborah Quail ^a,^{^{10
Tel.: +44 1276 483293 (office); fax: +44 (0) 1276 484800.}} , Andre Tylee ^i,^{^{11
Tel.: +44 20 7848 0150 (office); fax: +44 (0) 20 7848 0333.}}
^a Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, UK
^b Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, D-01307 Dresden, Germany
^c Hospital Universitario Salamanca, Avda Comuneros 27, Salamanca 37003, Spain
^d Unité de Psychiatrie, Hôtel-Dieu, 1 place du Parvis Notre Dame, 75004 Paris, France
^e Universitair Ziekenhuis Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
^f University of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy
^g Boehringer Ingelheim GmbH, D-55216 Ingelheim, Germany
^h The Gordon Hospital, Bloomburg Street, London SW1V 2RH, UK
ⁱ Section of Primary Care Mental Health, Health Services and Population Research Department, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK

Corresponding author. Tel.: +49 351 458 2772; fax: +49 351 458 43 24.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

pages	9
Iconographies	4
Vidéos	0
Autres	0

Abstract

Factors influencing outcomes of depression in clinical practice, especially health-related quality of life (HRQoL), are poorly understood. The Factors Influencing Depression Endpoints Research (FINDER) study is a European prospective, observational study designed to estimate the HRQoL of adults with a clinically diagnosed depressive episode at baseline, and 3 and 6 months after commencing antidepressant medication. We report here the study design and baseline patient characteristics.

HRQoL was assessed by the 36-item Short-Form Health Survey (SF-36) and European Quality of Life-5 Dimensions (EQ-5D). Patient ratings on Hospital Anxiety and Depression Scale (HADS) and pain Visual Analogue Scale (VAS) were also obtained. Results (n=3468) showed that SF-36 mental component summary (mean 22.2) was more than two SDs below general population norms (mean 50.0) and one SD below clinical depression norms (mean 34.8); the physical component summary (mean 46.1) was similar to general population (mean 50.0) and clinical depression norms (mean 45.0). Mean EQ-5D scores were also lower than general population norms. Mean HADS-Depression and -Anxiety subscores were 12.3 and 13.0, respectively. Fifty-six percent of patients reported an overall pain VAS score of at least 30mm and 70% of these patients had no physical explanation for their pain.

Further investigation into factors associated with HRQoL in depression after treatment initiation is warranted.

Le texte complet de cet article est disponible en PDF.

Keywords : Depression, Europe, Observational study, Quality of life

Plan

Introduction

Methods

Study design

Data collection and assessments

Statistical analysis

Results

Patient characteristics and psychiatric and medical histories

Baseline scores

Relationship between depression, HRQoL and pain at baseline

Discussion

Primary and secondary care settings

Criteria for patient inclusion

Longitudinal design

FINDER baseline results

Study limitations

FINDER was funded by Eli Lilly and Company Limited, Windleham, UK and Boehringer Ingelheim GmbH, Ingelheim, Germany.

Export

Vol 23 - N° 1

P. 57-65 - janvier 2008 Retour au numéro

Article précédent

Electroconvulsive therapy in the treatment of mixed states in bipolar disorder
Marc Valentí, Antoni Benabarre, Margarita García-Amador, Oriol Molina, Miquel Bernardo, Eduard Vieta

| Article suivant

Prescribing patterns of antidepressants in Europe: Results from the Factors Influencing Depression Endpoints Research (FINDER) study
Michael Bauer, Brigitta U. Monz, Angel L. Montejo, Deborah Quail, Nicolas Dantchev, Koen Demyttenaere, Ana Garcia-Cebrian, Luigi Grassi, David G.S. Perahia, Catherine Reed, Andre Tylee

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Factors influencing depression endpoints research (FINDER): Study design and population characteristics - 28/05/11

Abstract

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL