Second primary lung malignancy in head and neck cancer patients - 15/02/11
, M. Shahla a, I. Lardinois a, O. Gilbert b, O. Hanquet b, G. Tragas b, A. Van Meerhæghe b, P. Lothaire a
Corresponding author. Maandal, 6, 1652 Alsemberg, Belgium.Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Summary |
Introduction |
Second primary lung cancer (SPLC) is generally of poor prognosis in patients presenting with head and neck cancer.
Methods |
Between January2000 and June2008, 39 patients with head and neck squamous-cell carcinoma (HNSCC) patients diagnosed with SPLC were included.
Results |
Fourteen SPLC were classified as synchronous and 25 as metachronous. SPLC and HNSCC staging correlated (P=0.0496). Patients with metachronous tumor showed longer median overall survival than those with synchronous tumor (92.9months versus 15.7months; Hazard ratio (HR), 0.323; 95% CI, 0.042–0.559; P=0.0045). In the subgroup of 11 patients with SPLC diagnosed more than 5years after HNSCC, prognosis was better (128.1 versus 29.7months; HR, 0.288; 95% CI, 0.053–0.353; P<0.0001).
Discussion |
In the present study, in contrast to the literature, improved prognosis and survival were found in the subgroup in which SPLC developed more than 12months after initial HNSCC diagnosis, and even more specifically in that in which SPLC developed more than 5years after initial HNSCC diagnosis.
Conclusion |
SPLC in HNSCC is generally described as unequivocally aggressive and of poor prognosis. Metachronous SPLC, however, especially when diagnosed more than 5years after HNSCC, was clearly associated with better prognosis.
Le texte complet de cet article est disponible en PDF.Keywords : Head and neck cancer, Lung cancer, Second primary
Plan
Vol 128 - N° 1
P. 11-13 - janvier 2011 Retour au numéro
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