Association of Budd-Chiari syndrome and celiac disease - 19/11/10
Summary |
Background and aims |
An association between Budd-Chiari syndrome (BCS) and celiac disease (CD) is uncommon. The aims of our study were to investigate the etiology of BCS and to search for a particular HLA Ag pattern among patients.
Patients and methods |
BCS diagnosis was based on Doppler ultrasound and CD diagnosis on duodenal biopsy, transglutaminase (TGAb) and gliadin antibodies (GAb). Patients were screened for prothrombotic disorders and seven had a PCR-SSO test for HLA genotypes. Patients were treated with anticoagulants and gluten-free diet.
Results |
Nine patients were included; mean age 27 years (20–42); sex ratio (F/M) 2; mean follow-up duration 31 months (6–54). All patients had endoscopic and histological features of CD. GAb/TGAb were found in 78 % (n=7). Ag HLA found were HLA DQβ1*02 (n=6) and DQβ1*03 (n=3). Prothrombotic conditions identified were latent myeloproliferative disorder (n=1), protein C deficiency (n=1), probable factor V Leiden (n=1) and oral contraceptive use (n=1). No prothrombotic state could be identified in the five other patients.
Conclusion |
The BCS–CD association is relatively frequent in our country. Underlying prothrombotic conditions were absent in more than 50 % of cases, suggesting CD plays a role in the occurrence of thrombosis. HLA alleles found are strongly associated with CD, without any particular pattern for the BCS–CD association.
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Vol 34 - N° 11
P. 621-624 - novembre 2010 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.