Carvedilol ameliorates sympathetic nerve sprouting and electrical remodeling after myocardial infarction in rats - 08/09/10
, Zhibing Lu, Xiaorong Hu, Bo He, Qizhu Tang, Congxin Huang
Corresponding author. Tel.: +86 27 88041911 8072; fax: +86 27 88040334.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 5 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Background |
We hypothesized that carvedilol, a nonselective β-blocker, can exert antiarrhythmogenic effects by inhibiting sympathetic nerve sprouting and electrical remodeling at peri-infarct zones after myocardial infarction (MI).
Methods |
MI was induced by ligation of the coronary artery. The rats in the carvedilol group received 5.0mg/kg carvedilol twice a day. Eight weeks after MI, monophasic action potential duration (MAPD), effective refractory period (ERP) and the inducibility of ventricular arrhythmia at the peri-infarct zones were evaluated and compared with MI rats. After these studies, the expression of growth associated protein 43 (GAP43) and tyrosinehydroxylase (TH) at the peri-infarct zones were examined by western blot and RT-PCR analysis.
Results |
Eight weeks after surgery, carvedilol shortened the duration of the MAPD determined as 20% (MAPD20) and 90% (MAPD90) repolarization time (33±9ms and 110±18ms vs 21±6ms and 76±13ms, both P<0.05) and ERP (76±15ms vs 62±12ms, P<0.05), respectively. Carvedilol decreased the inducibility of ventricular arrhythmia after MI (76% vs 32%, P<0.05). The expression of GAP43 and TH were suppressed by carvedilol after MI.
Conclusion |
Carvedilol exerts antiarrhythmogenic effects by ameliorating sympathetic nerve sprouting and electrical remodeling in MI rats. The effects of carvedilol on amelioration of electrical remodeling may be partly related to the inhibition of sympathetic remodeling.
Le texte complet de cet article est disponible en PDF.Keywords : Myocardial infarction, Arrhythmias, Electrophysiology
Plan
Vol 64 - N° 7
P. 446-450 - septembre 2010 Retour au numéro
Article précédent
- Effect of low molecular weight heparin rectal suppository on experimental ulcerative colitis in mice
- Junyong Luo, Jichao Cao, Xueliang Jiang, Huifei Cui
- The mechanisms of somatostatin induced enhanced chemosensitivity of gallbladder cancer cell line to doxorubicin: Cell cycle modulation plus target enzyme up-regulation
- Zhi Wei Quan, Yong Yang, Ji Yu Li, Wei Gong, Yi Yu Qin, Song Gang Li
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?