Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses - 01/01/04
Bruce
Beutler
*
,
Kasper
Hoebe,
Louis
Shamel*Corresponding author.
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Résumé |
The innate immune system senses pathogens largely through signals initiated by proteins known as Toll-like receptors' (TLRs), of which ten representatives are known to be encoded in the human genome. The understanding of the biochemical circuitry that maintains the innate capacity for immune recognition and response has loomed as a major hurdle in immunology. A total of five adapter proteins with cytoplasmic domain homology to the TLRs are known to exist in mammals. These proteins show preferential association with individual TLR family members, giving a particular character to the signals that distinct microorganisms initiate, and also initiate the adaptive immune response. The adaptive immune response is dependent upon upregulation of costimulatory molecules (UCM) such as CD80 and CD86. Forward genetic analysis has revealed that this upregulation depends upon an adapter encoded by a locus known as Lps2, and upon type I interferon receptor signaling. To cite this article: B. Beutler et al., C. R. Biologies 327 (2004).
Mots clés : innate immune system ; Toll-like receptors' ; human genome ; adapter proteins ; type I interferon ; TLR family ; costimulatory molecule expression.
Plan
Vol 327 - N° 6
P. 571-580 - juin 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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