P01-356 - Casuistic series with escitalopram treatment of bpsd in patients with alzheimer’s disease - 08/06/10
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Résumé |
Objectives |
Behavioral and psychological symptoms of dementia (BPSD) are common during the course of dementia and are associated with poor outcome for patients. There are some clinical data indicating that SSRI antidepressants have a positive influence on BPSD. Escitalopram has an excellent side-effect profile and might be a suitable treatment for BPSD in older demented patients.
Methods |
An open-label observation of inpatients aged 65 to 90 years with a clinical diagnosis of probable AD and an MMSE score of 6 to 20 points and NPI total score ≥20 points treated with escitalopram for 8 weeks. The evaluation of improvement/worsening counted as ±10% change from baseline score in NPI and CMAI short. The results expressed in numbers of improved, unchanged and worsened patients.
Results |
13 patients, 12 women and 2 men. The average age was 79.3 years, the average MMSE was 12.8 points. Three patients discontinued due to AEs (bronchopneumonia, progressive worsening of dementia, transfer to another institution). The other AEs were mild and not related to study medication.
NPI patient scaleCMAI short scaleBaseline Day 1 (N=13)31.229.9Day 14 (N=13)27.126.9Day 28 (N=11)22023 7Day 56 (N=10)16.921 52 unchanged3 unchanged8 improved7 improved(5 of them much improved) defined as ≥62% reduction of score(5 of them much improved) defined as ≥38% reduction of score
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Conclusions |
Most patients exhibited a reduction of BPSD, half of them with a very substantial reduction. Patients exhibited very good tolerance of the medication.
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Vol 25 - N° S1
P. 569 - 2010 Retour au numéro
Article précédent
- P01-355 - Elderly chronic mental ill patients in community residence units
- L. Iliopoulou, A. Fotiadou, V. Koutras
- P01-357 - Temporal relationship of depression, cognitive impairment and dementia in older persons
- M. Ladea, C.M. Sinca
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