Anti-androgen Treatments - 24/02/10
, Nathalie Chabbert-Buffet b, Sylvie Salenave c, Véronique Kerlan d, Marie-Béatrice Galand-Portier e
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Abstract |
1. Estrogen plus progestin contraceptives (EPP) are the first-line treatment of moderate hirsutism and acne in women of child bearing age (grade C).
2. CPA, 50mg/day, 20 days out of 28, associated with estrogen is the first-line treatment of “moderate to severe hirsutism” in women of childbearing age (grade C).
3. Spironolactone, given as a contraceptive, can be proposed as a second-line treatment in case of side effects or counter-indications to CPA in moderate to severe hirsutism (grade C) in women of childbearing age. No market authorization in this indication.
4. Flutamide or Finasteride are “only” to be used under the guise of contraception as a “thirdline therapy” in cases of severe hirsutism, the presence of side effects or counter-indications to EPP, CPA 50mg/day or spironolactone (grade C). No market authorization in this indication
5. There is no indication for GnRH analogs as an anti-androgen treatment in women of childbearing age given the current therapeutic alternatives (grade C)
6. Only long-term hair removal treatments can be proposed (grade C): electrolysis or laser hair removal.
Le texte complet de cet article est disponible en PDF.Keywords : Anti-androgen, Estrogen plus progestin contraceptive, Spironolactone, Cyproterone Acetate, Futamide, Finasteride
Plan
Vol 71 - N° 1
P. 19-24 - février 2010 Retour au numéro
Article précédent
- Dépistage et prise en charge du déficit en 21-hydroxylase à révélation tardive chez les femmes avec hyperandrogénie
- J. Young, V. Tardy, A. Brac de la Perrière, A. Bachelot, Y. Morel
- Les traitements anti-androgènes
- A. Bachelot, N. Chabbert-Buffet, S. Salenave, V. Kerlan, M.-B. Galand-Portier
Bienvenue sur EM-consulte, la référence des professionnels de santé.