Cyclosporine diminishes multidrug resistance in K562/ADM cells and improves complete remission in patients with acute myeloid leukemia - 30/09/09
, Le-Xin Wang b, ⁎ , Chun-Bo Wang c, Shou-Guo Chen d
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Abstract |
This study was designed to investigate the effects of cyclosporine A (CsA) on a multidrug resistance cultured cell line, and its effect on complete remission in patients with acute myeloid leukemia (AML). A multidrug resistant K562/ADM cell line and drug-sensitive K562 cell line was used. The intracellular concentration of daunorubicin and the accumulation of Rhodamine 123 (Rh123) in the K562/ADM and K562 cells were evaluated. Clinical effects of CsA were also studied in 65 patients with AML. In the K562/ADM cells, the 50% of inhibition concentration (IC50) of daunorubicin only group was 23.0±5.2μmol/L, which was greater than in other groups co-administered with CsA (1.2±4.8μmol/L), verapamil (1.5±5.4μmol/L) or CsA+verapamil (1.4±4.3μmol/L) (all P<0.01). The relative fluorescence intensity of Rh123 in the K562/ADM cells treated with CsA and daunorubicin was increased from 48.9% to 69.8% (P<0.05). CsA also improved the complete remission rate in the AML patients (72.7% vs 21.9%, P<0.01). We conclude that CsA can significantly diminish the multidrug resistance in K562/ADM cells. It also enhances the complete remission rates in patients with AML. CsA may be used as an integral part of the chemotherapy for AML.
Le texte complet de cet article est disponible en PDF.Keywords : Leukemia, Acute myeloid leukemia, Cyclosporin A, Multidrug resistance, Cancer
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Vol 63 - N° 8
P. 566-570 - septembre 2009 Retour au numéro
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