High-fat diet may impair KATP channels in vascular smooth muscle cells - 02/02/09
, Zhi Hu a, Xiao-Jun Bai a, Yong-Xiao Cao c
Corresponding author at: Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Ion Channel Disease Laboratory, Key Laboratory of Environment and Genes related to Diseases of Education Ministry, No. 1 Jian Kang Road, Xi'an, Shaanxi 710061, China. Tel.: +86 29 8113 2116; fax: +86 29 8328 3696.Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
KATP channel in vascular smooth muscle cell (VSMC) is closely linked to the etiology of hypertension. The aim of this study was to investigate effect of the high-fat diet-induced obesity on KATP channel and blood pressure. Obesity was induced by a 24-week high-fat diet feeding in rats. Function and expression of KATP channel in mesenteric arteries were examined using myography system, patch clamp and Western blotting. We show that high-fat diet increased blood pressure, decreased KATP channel-mediated relaxation responses and currents, and down-regulated KATP expression in VSMC. In conclusion, diet-induced obesity impairs KATP channels in VSMC, which may underscore obesity-triggered increase in blood pressure.
Le texte complet de cet article est disponible en PDF.Keywords : Obesity, KATP channel, Hypertension
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Vol 63 - N° 2
P. 165-170 - février 2009 Retour au numéro
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