Synthesis and biological evaluation of decavanadate Na₄Co(H₂O)₆V₁₀O₂₈·18H₂O - 05/01/09

Doi : 10.1016/j.biopha.2008.01.006

Fengying Zhai ^a, Xiaohong Wang ^a,^⁎ , Dongliu Li ^a, He Zhang ^b, Rui Li ^c,^⁎, Liansheng Song ^b
^a Key laboratory of Polyoxometalate Science of Ministry of Education, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, PR China
^b Cancer Research on Prevention and Treatment, Changchun 130012, PR China
^c China–Japan Union Hospital, Jilin University, Changchun 130024, PR China

Corresponding authors. Tel.: +86 431 88930042; fax: +86 431 85099759.

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Abstract

We have reported the synthesis and biological evaluation of a decavanadate Na₄Co(H₂O)₆V₁₀O₂₈·18H₂O (CoV₁₀) designed as a potential antitumoral agent. The human cancer cell lines SMMC-7721 (liver cancer) and SK-OV-3 (ovary cancer) were tested for their viability by the MTT method in vitro, which showed that the compound exhibited a remarkable activity against two cell lines with IC₅₀ values smaller than 0.24μg/mL, 0.32μg/mL, respectively. CoV₁₀ showed the tumor growth suppression for Hep-A-22 (mice liver cancer) in tumor bearing mice in vivo. In addition, using flow cytometry analysis, the ratio of apoptotic cells was up to 8.33% with treatment of CoV₁₀ at 1.56μg/mL after 30min, suggesting that the antitumoral activity of CoV₁₀ comes from the activation of the apoptotic pathway.

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Keywords : Decavanadate, Antitumoral activity, Apoptosis

Plan

Introduction

Materials and methods

Chemicals and supplies

Cell lines and mice

Growth inhibition assay

Antitumoral activity test in vivo

Flow cytometric analysis

Results and discussion

Growth inhibition test in vitro

Inhibition of tumor growth in tumor bearing mice

Cell cycle and apoptosis distribution after treatment with CoV₁₀

Conclusions

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Vol 63 - N° 1

P. 51-55 - janvier 2009 Retour au numéro

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Synthesis and biological evaluation of decavanadate Na₄Co(H₂O)₆V₁₀O₂₈·18H₂O - 05/01/09

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