Association of calcium supplement with risk of incident arrhythmia - 25/04/25

Doi : 10.1016/j.jnha.2025.100565

Ru Chen ^a,^b,^{^{1
Contributed equally.}}, Duqiu Liu ^b,^c,^{^{1
Contributed equally.}}, Chenxing Yang ^d, Tianyu Guo ^e, Sen Liu ^e, Yi Guo ^b,^c, Jinjie Xiong ^a,^b, Shan Deng ^a,^b,⁎
^a Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
^b Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
^c Liyuan Cardiovascular Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
^d Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
^e Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, and State Key Laboratory of Environment Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

^⁎Corresponding author.

connectez-vous ou créez un compte

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Sous presse. Manuscrit accepté. Disponible en ligne depuis le Friday 25 April 2025
Cet article a été publié dans un numéro de la revue, cliquez ici pour y accéder

Abstract

Background and aims

Calcium plays a crucial role in cardiac electrophysiology, but the association between calcium supplement and the risk of incident arrhythmia remains unclear.

Objective

To investigate the relationship between habitual calcium supplement and incident risk of cardiac arrhythmia.

Methods

We conducted a prospective study of 480,972 participants from the UK Biobank. Habitual calcium supplement was treated as the main exposure. The primary outcome was the incidence of arrhythmias, including atrial fibrillation/flutter (AF/AFL), ventricular arrhythmia (VA), and bradyarrhythmia. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

After a median follow-up of 11.69 years, 46,609 incident arrhythmia cases were documented, including 36,406 AF/AFL, 5,370 VA, and 14,226 bradyarrhythmia. After multivariable adjustment, calcium supplement was associated with an increased risk of total arrhythmias (HR 1.11, 95% CI 1.05–1.19), AF/AFL (HR 1.20, 95% CI 1.12–1.28), VA (HR 1.14, 95% CI 1.07–1.21), and bradyarrhythmia (HR 1.18, 95% CI 1.11–1.26). Significant interactions were observed between calcium supplement and estimated glomerular filtration rate, diabetes, cardiovascular disease, and polygenic risk score for AF (all p for interaction < 0.05).

Conclusions

Calcium supplement was associated with an increased risk of incident arrhythmia. Careful evaluation of the potential arrhythmic risk is warranted when considering calcium supplement in individuals with clinical indications.

Le texte complet de cet article est disponible en PDF.

Keywords : Calcium supplement, Atrial fibrillation, Ventricular arrhythmia, Bradyarrhythmia, Incident risk