Extensive dissemination of ESBL-producing Clonal Complex 14 Escherichia coli is likely spread through sexual transmission among men who have sex with men at risk of sexually transmitted infections - 08/04/25
Summary |
Objectives |
We characterized the genetic proximity of Sequence Type (ST) 131, 1193 and 14 Extended-Spectrum Beta-Lactamase-producing E. coli (ESBL-Ec) to assess human determinants of carriage in community settings.
Methods |
In this cross-sectional study, we included individuals seeking care at a sexually transmitted infection (STI) or HIV outpatient clinic. ESBL-Ec were compared using phylogeny, core-genome Multi-Locus Sequence Typing and Single-Nucleotide Polymorphism (SNP) determination. Determinants were compared between STs and correlated to genetic distances.
Results |
103 individuals carried 112 strains of ST131 (n=63), ST14 (n=26) and ST1193 (n=23). Compared to ST131, ST14 isolates were more commonly found in individuals with any STI (p=0.031), men who have sex with men (p<0.001) and recent antibiotic use (p=0.021); whereas ST1193 isolates were more commonly found in individuals who engaged in insertive anal sex in <6 months (p=0.017). ST131 isolates showed high genomic diversity, while other STs evidenced a high level of proximity. SNPs data indicated the likely spread of a single ST14 (range=1;32) and some ST1193 clusters (range=2;111), which were linked to ST-specific sexual behaviors.
Conclusions |
In populations of those at risk of acquiring STI, ST14 and ST1193 ESBL-Ec are emerging. Specific sexual transmissions routes are likely to play a role in their spread.
Le texte complet de cet article est disponible en PDF.Highlights |
• | ESBL Clonal Complex 14 E. coli recently spread among men who have sex with men. |
• | Sexual behaviors and antibiotics increase ESBL Clonal Complex 14 E. coli carriage. |
• | Core-genome comparison and phylogeny enable transmission routes characterization. |
Keywords : Extended-Spectrum Beta-lactamase producing E. coli carriage, ST14 E. coli, ST1193 E. coli, Molecular epidemiology, Molecular typing
Plan
Vol 90 - N° 4
Article 106453- avril 2025 Retour au numéro
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