Global epidemiology, seasonality and climatic drivers of the four human parainfluenza virus types - 08/04/25

Doi : 10.1016/j.jinf.2025.106451

Yi Song ^a,^b, Yu-Nong Gong ^c,^d,^e,^f, Kuan-Fu Chen ^c,^g,^h, David K. Smith ^a,^b, Hassan Zaraket ⁱ, Seweryn Bialasiewicz ^j, Sarah Tozer ^k, Paul KS Chan ^l, Evelyn SC Koay ^m,ⁿ, Hong Kai Lee ⁿ, Kok Keng Tee ^o, Pieter LA Fraaij ^p,^q, Lance Jennings ^r, Matti Waris ^s,^t, Hidekazu Nishimura ^u, Aripuana Watanabe ^v, Theo Sloots ^w,^x, Jen Kok ^y,^z, Dominic E. Dwyer ^z,^aa, Marion PG Koopmans ^q, David W. Smith ^ab,^ac, Julian W. Tang ^ad,^ae, Tommy TY Lam ^a,^b,^af,^ag,^ah,^⁎
on behalf of the INSPIRE consortium^¹
See Appendix A for Contributors of INSPIRE consortium.
^a State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong SAR, China
^b Laboratory of Data Discovery for Health, Hong Kong SAR, China
^c Research Center of Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
^d International Master Degree Program for Molecular Medicine in Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
^e Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
^f National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan
^g College of Intelligent Computing, Chang Gung University, Taoyuan, Taiwan
^h Department of Emergency Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan
ⁱ Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
^j Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
^k Patient Safety and Quality, Clinical Excellence Queensland, Department of Health, Queensland Health, Australia
^l Department of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR, China
^m Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
ⁿ Molecular Diagnosis Centre, National University Hospital, Singapore
^o Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
^p Department of Pediatrics, Erasmus Medical Centre, Rotterdam, the Netherlands
^q ViroScience, Erasmus Medical Centre, Rotterdam, the Netherlands
^r Canterbury Health Laboratories and Department of Pathology & Biomedical Sciences, University of Otago, Christchurch, New Zealand
^s Institute of Biomedicine, University of Turku, Finland
^t Clinical Microbiology, Turku University Hospital, Turku, Finland
^u Virus Research Center, Sendai Medical Center, Sendai, Japan
^v Department of Parasitology, Microbiology and Immunology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
^w Child Health Research Centre, The University of Queensland, Brisbane, Australia
^x Children's Health Queensland, Brisbane, Australia
^y Centre for Infectious Disease and Microbiology Laboratory Services, NSWHP-Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
^z Centre for Infectious Diseases-Public Health, Westmead Hospital, Westmead, New South Wales, Australia
^aa Pathology and Infectious Diseases, University of Sydney, Sydney, Australia
^ab PathWest Laboratory Medicine, Perth, Western Australia, Australia
^ac School of Medicine, University of Western Australia, Perth, Western Australia, Australia
^ad Department of Respiratory Sciences, University of Leicester, Leicester, UK
^ae Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, UK
^af Centre for Immunology & Infection, Hong Kong SAR, China
^ag HKU-Pasteur Research Pole, Hong Kong SAR, China
^ah The Hong Kong Jockey Club Global Health Institute, Hong Kong SAR, China

^⁎Correspondence to: 5/F, Laboratory Block, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.5/F, Laboratory Block, Li Ka Shing Faculty of Medicine, 21 Sassoon RoadPokfulamHong Kong SARChina

Summary

Objectives

Human parainfluenza viruses (hPIV) are a common cause of acute respiratory infections, especially in children under five years and the elderly. hPIV can be subclassified as types 1–4: these showed various seasonality patterns worldwide, and it is unclear how climatic factors might consistently explain their global epidemiology.

Methods

This study collected time-series incidence data from the literature and hPIV surveillance programs worldwide (47 locations). Wavelet analysis and circular statistics were used to detect the seasonality and the months of peak incidence for each hPIV type. Relationships between climatic drivers and incidence peaks were assessed using a generalized estimating equation.

Results

The average positive rate of hPIV among patients with respiratory symptoms was 5.6% and ranged between 0.69–3.48% for different types. In the northern temperate region, the median peak incidence months for hPIV1, hPIV2, and hPIV4 were from September to October, while for hPIV3, it was in late May. Seasonal peaks of hPIV3 were associated with higher monthly temperatures and lower diurnal temperatures range throughout the year; hPIV4 peaks appeared to correlate with lower monthly temperatures and higher precipitation throughout the year. Different hPIV types exhibit different patterns of global epidemiology and transmission.

Conclusions

Climate drivers may play a role in hPIV transmission. More comprehensive and coherent surveillance of hPIV types would enable more in-depth analyses and inform the timing of preventive measures.

Le texte complet de cet article est disponible en PDF.

Highlights

•	Global type-specific hPIV incidence time-series data enables detailed analysis of seasonality.
•	hPIV3 shows a different seasonality across many regions, compared to the hPIV1, 2 & 4.
•	Increases in hPIV3 incidence are correlated with higher temperatures.

Le texte complet de cet article est disponible en PDF.

Keywords : Parainfluenza virus, Seasonality, Incidence, Surveillance, Climatic factors

Plan

Introduction

Methods

Data collection

Case data from longitudinal studies

Climatic data

Data analysis

Impact of climatic factors on the seasonal peaks

Role of the funding source

Results

Positive rates of hPIV1-4 among different populations showing respiratory symptoms

Seasonality and peak months of hPIV1-4 by site

Effects of climatic factors on the incidence of hPIV

Discussion

Funding

Author contributions

Export

Vol 90 - N° 4

Article 106451- avril 2025 Retour au numéro

Article précédent

Increased circulation of adenovirus in China during 2023-2024: Association with an increased prevalence of species B and school-associated transmission
Ronghua Jin, Tian Qin, Pei Li, Jiale Yuan, Hui Li, Ying Liu, Min Wang, Jianguo Xu, Yamin Sun

| Article suivant

Effectiveness of nirsevimab in preventing RSV-hospitalisation among young children in Western Australia 2024
Ushma Wadia, Hannah C. Moore, Peter C. Richmond, Avram Levy, Lana Bell, Catherine Pienaar, Joanne Harvey, Caroline Finucane, Erin van der Helder, Lauren Bloomfield, Allen Cheng, Paul Effler, Christopher C. Blyth

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Global epidemiology, seasonality and climatic drivers of the four human parainfluenza virus types - 08/04/25

Summary

Objectives

Methods

Results

Conclusions

Highlights

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL