This article explores the critical role of standardized communication structures and handoff tools in enhancing the safety-of-care transitions. We highlight the complexity and vulnerability of these transitions, particularly between different care environments and providers, which can lead to miscommunication and medical errors. Various types of handoffs are discussed, along with their respective benefits and challenges. We underscore the importance of effective discharge planning and communication to reduce readmissions and ensure patient safety. Best practices for discharge safety, such as patient education, medication reconciliation, and purposeful follow-up, are detailed to improve the quality-of-care transitions.