Human papillomavirus genotype distribution among high-grade cervical lesions in French women born between 1972 and 1993 - 24/03/25

Doi : 10.1016/j.jogoh.2025.102945

Philomène Lenoir ^a, Julie Guillet ^b, Maxime Desmarets ^c, Alice Baraquin ^d, Rajeev Ramanah ^a, Justine Rousse ^c, Christiane Mougin ^d,^e, Quentin Lepiller ^d,^f,^g, Jean-Luc Prétet ^d,^f,^h,^⁎
HPV Impact Study Group
^a CHU Besançon, Service de Gynécologie, F-25000 Besançon, France
^b Département de Chirurgie Orale, Faculté d'Odontologie de Lorraine, Université de Lorraine, Nancy, France
^c CHU Besançon, Unité de méthodologie en recherche clinique épidémiologique et santé publique, F-25000 Besançon, France
^d CHU Besançon, Centre National de Référence Papillomavirus, F-25000 Besançon, France
^e Université Marie et Louis Pasteur, UMR U1098 RIGHT, F-25000 Besançon, France
^f Université Marie et Louis Pasteur, CHU Besançon, CNRS, Chrono-environnement (UMR 6249), F-25000 Besançon, France
^g CHU Besançon, Laboratoire de virologie, F-25000 Besançon, France
^h CHU Besançon, Laboratoire de biologie cellulaire, F-25000 Besançon, France

^⁎Correspondence to: Jean-Luc Prétet, Laboratoire de Biologie Cellulaire et Moléculaire, CHU de Besançon 3, Boulevard Fleming, 25030, Besançon France. Phone number: +33(0)3 70 63 20 49Laboratoire de Biologie Cellulaire et MoléculaireCHU de Besançon 3Boulevard FlemingBesançon25030France

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ABSTRACT

Background

Implementation of HPV vaccination programmes may induce significant changes in the distribution of HPV genotypes detected in cervical (pre-)cancers.

Methods

In a multicentre study in France, we investigated the distribution of HPV genotypes using a sensitive molecular technique in 611 histological specimens diagnosed with high-grade lesions (CIN2/3) in a large cohort of women born between 1972 and 1993. Women born after 1983 were potentially vaccinated because of their young age.

Results

High-risk HPV genotypes were detected in 93.4% of women and 24.4% had a multiple infections. HPV16/18 genotypes were more frequently associated with CIN3 than with CIN2 lesions (66% vs. 57%, p=0.045). The prevalence of HPV16 and HV18 genotypes did not change according to the year of birth.

Conclusion

Contrary to previous descriptions in countries with a high HPV vaccination coverage, we did not observe difference in the prevalence of HPV16 and HPV18 genotypes in CIN2/3 lesions after the introduction of HPV vaccination in France, in a context of low national vaccination coverage.