Incidence of RSV-related hospitalizations for ARIs, including CAP: Data from the German prospective ThEpiCAP study - 05/03/25
, Elizabeth Begier b , Stefan Hagel c , Juliane Ankert c , Liz Wang a , Claudia Schwarz d , Lea J. Bayer e , Christof von Eiff e , Qing Liu d , Jo Southern d , Jeffrey Vietri d , Sonal Uppal d , Bradford D. Gessner d , Christian Theilacker d , Mathias W. Pletz c, ⁎ Summary |
Background |
RSV is a leading cause of ARI, including CAP, in older adults. Data available often underestimate RSV-related ARI incidence. We estimated RSV-related ARI hospitalization incidence from a prospective CAP study, adjusting for undiagnosed RSV infections due to nasopharyngeal/nasal swab testing only.
Methods |
Active surveillance of adult CAP hospitalizations in Germany was conducted between 2021–2023. Nasopharyngeal/nasal swabs were RSV-tested, and age-group specific proportions were applied to calculate RSV-related CAP incidence. This was divided by the CAP proportions among RSV-related ARI hospitalizations (from multispecimen study) to extrapolate RSV-related ARI rates.
Results |
Among 1040 radiologically confirmed CAP cases, 3.7% tested RSV-positive via nasopharyngeal/nasal swab, corresponding to 7.8% after adjusting for underdetection. For 18–59 and ≥60 years, adjusted RSV-related CAP hospitalization rates (95% CI) were 4.9 (1.8–10.9) and 115.6 (78.8–163.6); adjusted RSV-related ARI hospitalization rates were 19.8 (6.8–50.1) and 401.6 (260.7–609.3) per 100,000, respectively. Within 30 days of an RSV-related CAP admission, 18.2% of those ≥65 years died, and 11.1% and 36.4% had cardiovascular events among those 18–64 and ≥65 years, respectively.
Conclusions |
Older adults in Germany experience a high burden of RSV-related ARI hospitalizations, including CAP, underscoring RSV vaccination’s potential utility for this population.
Le texte complet de cet article est disponible en PDF.Highlights |
• | RSV incidence is underestimated due to infrequent testing and low-test sensitivity. |
• | We estimated RSV hospitalization incidence, accounting for undiagnosed cases. |
• | RSV-related ARI hospitalization incidence among those ≥60 years was 401.6/100,000. |
• | There is a substantial burden of RSV among adults in Germany. |
• | 36.4% of RSV hospitalizations in older adults had associated cardiovascular events. |
Keywords : Community-acquired pneumonia, Respiratory syncytial virus, Acute respiratory infection, Hospitalization
Plan
Vol 90 - N° 3
Article 106440- mars 2025 Retour au numéro
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