Health-associated quality of life impairment in people who inject drugs (PWID) after bloodstream infection - 03/01/25
Summary |
Background |
People who inject drugs (PWID) have high rates of bloodstream infections (BSI) with Staphylococcus aureus (SA) and group A streptococcus (GAS). Little is known about health-related quality of life outcomes after BSI.
Methods |
We performed a prospective pilot cohort study of patients with BSI due to SA or GAS. Health-related quality of life, anxiety, depression and cognitive function were assessed using validated tools (EQ5-5D-5L), Hospital Anxiety and Depression Score (HADS) and Montreal Cognitive Assessment (MOCA) at baseline, 28 days post-discharge and 6 months post-infection.
Findings |
66 patients were recruited over a 12-month period, including 17 PWID. For the whole cohort, global health rank improved from baseline to day 28 (median 40 to 60, p=0.002), with no significant improvement from day 28 to day 168 (median 60 to 75, p=0.161). At baseline, PWID had lower overall health-related quality of life than non-PWID (median 25 vs 45, p=0.229), persisting at day 28 (non-PWID median 65, PWID median 43, p=0.036) and day 168 (non-PWID median 75, PWID median 40, p=0.035). This difference was driven by worse scores in the EQ-5D-5L mental health component and HADS, with HADS scores being significantly impaired in PWID at baseline (p=0.001) and day 28 (p=0.007).
Conclusion |
PWID have impaired health-related quality of life after SA and GAS BSI that persists for up to 6 months. Poor mental health is the major component of this, and further studies could clarify if this is a target for intervention.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Quality of life scores are impaired after BSI with Staphylococcus aureus or Group A streptococcus. |
• | Recovery of quality of life is slower in people who inject drugs (PWID). |
• | Poor mental health is the driver for this impairment, with prolonged increased anxiety and depression in PWID. |
Keywords : Quality of life, People who inject drugs, Staphylococcus aureus, Bloodstream infection
Plan
Vol 90 - N° 1
Article 106375- janvier 2025 Retour au numéro
Article précédent
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