The association between rickettsial infection and hyperinflammation, diagnostic and management challenges - 03/01/25
Doi : 10.1016/j.jinf.2024.106372
Sophie Skarbek 1 
Department of Infectious Diseases and Tropical medicine, Sheffield Teaching Hospitals, Sheffield, United Kingdom
Thomas HA Samuels, 1
Hospital for Tropical Diseases, Division of Infection, UCLH NHS Trust, London, United Kingdom
Division of Infection and Immunity, University College London, London, United Kingdom
Sana Sharrack 1
Department of Rheumatology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Foundation Trust, Leeds, United Kingdom
Danielle Cohen
Department of Infectious Diseases and Tropical medicine, Sheffield Teaching Hospitals, Sheffield, United Kingdom
Rachel S. Tattersall
Department of Rheumatology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
Michael Brown 1
Hospital for Tropical Diseases, Division of Infection, UCLH NHS Trust, London, United Kingdom
Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom
James E. Meiring 1, ⁎
Department of Infectious Diseases and Tropical medicine, Sheffield Teaching Hospitals, Sheffield, United Kingdom
School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom
∗Corresponding author at: Department of Infectious Diseases and Tropical medicine, Sheffield Teaching Hospitals, Sheffield, United Kingdom.Department of Infectious Diseases and Tropical medicine, Sheffield Teaching HospitalsSheffieldUnited Kingdom
Highlights |
• | There is an increasing recognition of the association between rickettsial infection and a hyperinflammatory state. |
• | Haemophagocytic lymphohistiocytosis should be considered with raised ferritin, persistent fever and falling blood counts. |
• | Consideration of immunomodulation therapy is challenging in this patient cohort, so multidisciplinary working is essential. |
© 2024
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 90 - N° 1
Article 106372- janvier 2025 Retour au numéro
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