Postprandial Inflammation Across the Aging Spectrum - 25/12/24

Doi : 10.1016/j.jnha.2024.100468

Bryant H. Keirns ^a, Natalie G. Keirns ^a, Christina M. Sciarrillo ^b, Austin R. Medlin ^c, Sarah E. Fruit ^a, Sam R. Emerson ^b,⁎
^a Department of Nutrition and Health Science, Ball State University, Muncie, IN 47306
^b Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, 74075
^c Department of Health & Wellness Design, Indiana University School of Public Health, Bloomington, IN 47405

^⁎Corresponding author.

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Highlights

•	High-fat meal consumption increased IL-6, IL-8, and IL-1β in the full sample.
•	Examined categorically, postprandial cytokines and age were largely unrelated.
•	Examined continuously, postprandial IL-6 was positively associated with age.

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Abstract

Objectives

Postprandial inflammation post-high-fat meals may be linked to cardiovascular disease (CVD). CVD incidence increases with age; however, whether older adults experience greater postprandial inflammation remains unclear. We examined whether analyzing age categorically versus continuously influenced relationships between age and postprandial inflammatory measures.

Design

Cross-sectional.

Setting

Laboratory for Applied Nutrition and Exercise Science at Oklahoma State University (Stillwater, OK, USA).

Participants

56 apparently healthy adults ages 20-69 years.

Measurements

We measured interleukin (IL)-1β, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α at baseline, 2-, 4-, and 6 -hs post-high-fat meal (9 kcal/kg; 70% fat). Data were examined in the full sample with paired t-tests (baseline to peak), by pre-defined age groups (i.e., 18-35, 36-49, 50-59, 60-69) using ANCOVA, and continuously using linear regression.

Results

Across the full sample, IL-1β, IL-6, and IL-8 increased after the high-fat meal (p’s≤0.018). Cytokine differences post-high-fat meal by age category were generally not observed. However, age was positively associated with IL-6 incremental AUC when examined continuously (b = 0.029; p = 0.010).

Conclusion

These data suggest increasing age is linked to a greater IL-6 response to a high-fat meal. Further, examining age continuously may have greater utility when studying aging and postprandial inflammation.