Up-regulated fatty acid-binding protein 4 promoted cardiac injury during open colorectal surgery in elderly patients - 12/12/24
Highlights |
• | Open surgery induces FABP4 expression in adipose tissue. |
• | Open surgery causes cardiac injury. |
• | There is strong association between FABP4 and cardiac injury. |
• | Adipose tissue may be involved in cardiac injury by inducing FABP4 expression. |
Summary |
Background |
Fatty acid binding protein 4 (FABP4) has been shown to increase cardiovascular disease. The FABP4 levels in serum and adipose tissue and the possible regulatory mechanisms during colorectal cancer surgery in elderly patients remain unknown.
Methods |
Four hundred elderly patients with colorectal cancer were recruited, 200 underwent laparoscopic surgery (LS) and 200 underwent open surgery (OS). Blood samples and mesenteric adipose tissue were collected at T1 (beginning of surgery) and T2 (end of surgery). Immunohistochemistry and biochemical analysis were used to evaluate the FABP4, cardiac troponin T (cTnT), creatine kinase-MB (CK-MB) and myoglobin (MYO) levels. Correlations between FABP4 and cTnT, CK-MB, MYO were further analyzed.
Results |
The expressions of FABP4 in mesenteric adipose tissue were significantly increased at T2 than T1 in OS group. The serum levels of FABP4, cTnT, CK-MB and MYO were significantly increased at T2 than T1 in OS group, and the OS group induced higher FABP4, cTnT, CK-MB and MYO levels than LS group at T2. Pearson's correlation analysis revealed that serum levels of FABP4 were strongly correlated with cTnT, CK-MB, and MYO.
Conclusions |
OS induced significantly increased FABP4 expressions in adipose tissue and caused cardiac injury in elderly patients with colorectal cancer. FABP4 is closely associated with cardiac injury, raising the possibility that adipose tissue may be causally involved in the pathogenesis of heart dysfunction during open surgery.
Le texte complet de cet article est disponible en PDF.Keywords : Fatty acid-binding protein 4, Adipose tissue, Cardiac injury, Open surgery, Laparoscopic surgery
Abbreviations : FABP4, ASA, TEE, cTnT, CK-MB, MYO, MAP, HR, CI, CO, EF, BIS, IAP
Plan
Vol 161 - N° 6
P. 364-371 - décembre 2024 Retour au numéro
Article précédent
- French practice of emergency resuscitative thoracotomy. A study based on the Traumabase Registry
- Hilaire de Malleray, Henri de Lesquen, Guillaume Boddaert, Mathieu Raux, Valentin Lefrançois, Nathalie Delhaye, Pauline Ponsin, Anaïs Cordorniu, Thierry Floch, Fanny Bounes, Elisabeth Gaertner, Alexia Hardy, Julien Bordes, Éric Meaudre, Michael Cardinale
- Surgical management of penetrating neck wounds. An update on surgical management. Part n°2 – in-hospital management
- Willem Paillusson, Rajvansh Sesmun, Catherine Arvieux, Paul Balandraud, Emmanuel Martinod, Paulina Kuczma, Christophe Tresallet
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?