Effect of respiratory rehabilitation on quality of life in individuals with post-COVID-19 symptoms: a randomised controlled trial - 08/12/24
, Raúl Fabero-Garrido 2 , Gustavo Plaza-Manzano 3, ⁎ , Juan Izquierdo-García 4 , Mireya López-Sáez 5 , Rocío García-García 6 , Ibai López-de-Uralde-Villanueva 1
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Highlights |
• | We evaluated combined respiratory muscle training + aerobic exercise |
• | Combined training increases respiratory endurance and strength |
• | Combined training has no additional impact on quality of life or exercise tolerance |
• | Combined training has no additional impact on lung function or psychological status |
• | Combined training is indicated in individuals with respiratory muscle weakness |
Abstract |
Background |
Inspiratory and expiratory muscle training (RMT) has been shown to have beneficial effects in individuals with long-term post-COVID-19 symptoms.
Objective |
To assess the effects of adding RMT to an aerobic exercise (AE) training program for health-related quality of life (HRQoL) and exercise tolerance in individuals with long-term post-COVID-19 symptoms, and to evaluate the effects on physical and lung function, and psychological status.
Methods |
64 individuals with long-term post-COVID-19 symptoms of fatigue and dyspnoea were randomly assigned to AE+RMT or AE+RMTsham groups for an 8-week intervention (AE: 50min/day, 2 times/week; RMT: 40min/day, 3 times/week). Primary outcomes were HRQoL (EuroQol-5D questionnaire) and exercise tolerance (cardiopulmonary exercise test). Secondary outcomes were physical function: respiratory muscle function (inspiratory/expiratory muscle strength and inspiratory muscle endurance), lower and upper limb strength (1-min Sit-to-Stand and handgrip force); lung function: spirometry testing and lung diffusing capacity; and psychological status (anxiety/depressive levels).
Results |
Postintervention, there were no statistically significant improvements in HRQoL or exercise tolerance in the AE+RMT compared with the AE+RMTsham group. In the AE+RMT group, large improvements in respiratory muscle function (d = 0.7 to 1.3) and low-moderate improvements in peak expiratory flow (d=0.4) occurred compared with the AE+RMTsham group. Lung function outcomes, lower and upper limb strength and psychological status did not increase more in the AE+RMT group than in the AE+RMTsham group.
Conclusion |
For individuals with long-term post-COVID-19 symptoms, combining RMT with an AE training program resulted in improvements in respiratory muscle strength, inspiratory muscle endurance and peak expiratory flow; however, the differences between groups were not statistically significant for HRQoL, exercise tolerance, psychological distress, and lung diffusing capacity.
Database registration |
United States Clinical Trials Registry (NCT05597774)
Le texte complet de cet article est disponible en PDF.Keywords : Aerobic exercise, Exercise tolerance, Long-term post-COVID-19 symptoms, Maximal respiratory pressures, Quality of life, Respiratory muscle training
Abbreviations : 1-min STS, AE, ANOVA, COVID-19, DLCO, EQ, HRQoL, IME, KCO, MEP, MIP, PCR, Peak VO2, PEF, RMT, SARS-CoV-2, VAS
Plan
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